ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: large tumor suppressor kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131023 LATS1 9606 - 6:149658153-149718256 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000253339 LATS1-005 149661094-149702354 protein_coding
  ENST00000392273 LATS1-003 149682919-149718105 protein_coding
  ENST00000441107 LATS1-004 149661697-149716425 nonsense_mediated_decay
  ENST00000458696 LATS1-007 149684325-149718034 protein_coding
  ENST00000542720 LATS1-002 149684404-149718024 nonsense_mediated_decay
  ENST00000542747 LATS1-006 149675696-149701963 processed_transcript
  ENST00000543571 LATS1-001 149658153-149718256 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000253339ENST00000392273ENST00000441107ENST00000458696ENST00000542747ENST00000543571
Transcript ID BECs HAoEC HUVEC
ENST00000253339 N/A 2.308±0.89 1.939±1.20
ENST00000392273 N/A 0.967±0.33 1.480±0.57
ENST00000441107 N/A 1.092±0.01 0.801±0.00
ENST00000458696 0.796±0.00 N/A N/A
ENST00000542747 N/A 0.862±0.00 1.757±0.86
ENST00000543571 N/A 2.420±1.54 2.281±1.84

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 IDA G2/M transition of mitotic cell cycle
GO:0000287 IDA magnesium ion binding
GO:0000819 IDA sister chromatid segregation
GO:0000922 IDA spindle pole
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0007067 IEA mitotic nuclear division
GO:0009755 ISS hormone-mediated signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IPI protein kinase binding
GO:0030216 IEA keratinocyte differentiation
GO:0030833 IDA regulation of actin filament polymerization
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034613 IEA cellular protein localization
GO:0035329 IDA hippo signaling
GO:0043254 IMP regulation of protein complex assembly
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051220 IMP cytoplasmic sequestering of protein
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003751 lats1 protein_coding Danio_rerio
ENSMUSG00000040021 Lats1 protein_coding Mus_musculus

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