Warning (512): _cake_core_ cache was unable to write 'cake_dev_eng' to File cache [CORE/Cake/Cache/Cache.php, line 323]
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                ),
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$value = array(
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$config = '_cake_core_'
$settings = array(
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$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
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$config = '_cake_model_'
$settings = array(
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	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
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)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
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$value = array(
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$config = '_cake_model_'
$settings = array(
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$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
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$key = 'default_angiogenes_genes'
$value = null
$config = '_cake_model_'
$settings = array(
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	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
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)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 301
GeneController::show() - APP/Controller/GeneController.php, line 301
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

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Gene Info
Description:	adenylosuccinate lyase
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000239900	ADSL	9606	+	22:40346500-40369367	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000216194		ADSL-017	40346528-40366614	protein_coding
	ENST00000342312		ADSL-002	40346503-40366996	protein_coding
	ENST00000423176		ADSL-009	40364962-40368038	protein_coding
	ENST00000466863		ADSL-003	40346518-40350323	retained_intron
	ENST00000477111		ADSL-005	40346529-40359302	retained_intron
	ENST00000480775		ADSL-006	40358968-40363053	nonsense_mediated_decay
	ENST00000623063		ADSL-001	40346500-40369367	protein_coding
	ENST00000623287		ADSL-012	40346530-40361577	nonsense_mediated_decay
	ENST00000623387		ADSL-015	40364558-40366556	retained_intron
	ENST00000623632		ADSL-010	40346500-40361313	protein_coding
	ENST00000623978		ADSL-011	40346529-40361566	protein_coding
	ENST00000624027		ADSL-016	40364962-40368105	protein_coding
	ENST00000624474		ADSL-013	40346532-40360431	nonsense_mediated_decay
	ENST00000624503		ADSL-007	40346518-40352055	nonsense_mediated_decay
	ENST00000625194		ADSL-014	40354259-40366517	protein_coding

Expression Patterns Split around values. Cell Line Name Tissue Condition Heat Map Numeric Values Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC ENST00000216194 N/A 57.691±30.11 N/A 36.184±0.00 38.109±13.68 ENST00000342312 N/A 17.622±0.63 N/A N/A 25.314±10.96 ENST00000625194 82.219±4.74 N/A 47.025±0.00 N/A N/A

Conserved Regions
Region ID	Sub-Region	Region Type
CIL_0006F2	CIL_0006F2_0001	CGP

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0001666	IEA	response to hypoxia
GO:0003824	IEA	catalytic activity
GO:0004018	IDA:IEA	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0005739	IEA	mitochondrion
GO:0005829	TAS	cytosol
GO:0006144	TAS	purine nucleobase metabolic process
GO:0006163	IEA	purine nucleotide metabolic process
GO:0006164	IC	purine nucleotide biosynthetic process
GO:0006167	IDA	AMP biosynthetic process
GO:0006189	IEA	'de novo' IMP biosynthetic process
GO:0007584	IEA	response to nutrient
GO:0008152	IDA	metabolic process
GO:0009060	IEA	aerobic respiration
GO:0009152	IEA	purine ribonucleotide biosynthetic process
GO:0009156	IEA	ribonucleoside monophosphate biosynthetic process
GO:0009168	TAS	purine ribonucleoside monophosphate biosynthetic process
GO:0014850	IEA	response to muscle activity
GO:0042594	IEA	response to starvation
GO:0044208	IEA	'de novo' AMP biosynthetic process
GO:0044281	TAS	small molecule metabolic process
GO:0051262	IDA	protein tetramerization
GO:0055086	TAS	nucleobase-containing small molecule metabolic process
GO:0070626	IEA	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000017049	adsl		protein_coding	Danio_rerio
ENSMUSG00000022407	Adsl		protein_coding	Mus_musculus

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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

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			(int) 4 => '`Gene`.`chromosome`',
			(int) 5 => '`Gene`.`strand`',
			(int) 6 => '`Gene`.`start`',
			(int) 7 => '`Gene`.`end`',
			(int) 8 => '`Gene`.`gene_name`',
			(int) 9 => '`Gene`.`gene_source`',
			(int) 10 => '`Gene`.`gene_biotype`',
			(int) 11 => '`Gene`.`annotation_version`',
			(int) 12 => '`Gene`.`gene_description`'
		)
	)
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/angiogenes/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??