ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062209 Erbb4 10090 - 1:68032186-69108059 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000119142 Erbb4-002 68032186-69107756 protein_coding
  ENSMUST00000121473 Erbb4-001 68032186-69108059 protein_coding
  ENSMUST00000126682 Erbb4-003 68298150-68330216 retained_intron
  ENSMUST00000131148 Erbb4-005 68290155-68298318 processed_transcript
  ENSMUST00000153432 Erbb4-004 68250655-69107756 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000119142ENSMUST00000121473ENSMUST00000153432
Transcript ID C166 Tie2+ EC mES
ENSMUST00000119142 N/A 0.018±0.00 N/A
ENSMUST00000121473 0.055±0.03 N/A N/A
ENSMUST00000153432 0.063±0.00 N/A 0.024±0.01

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000164 CIL_000164_0002 CGP
CIL_00083V CIL_00083V_0002 VISTA
CIL_0006PA CIL_0006PA_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001755 IMP neural crest cell migration
GO:0004714 ISS transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005739 IEA mitochondrion
GO:0006351 IEA transcription, DNA-templated
GO:0007165 IEA signal transduction
GO:0007169 ISS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IMP nervous system development
GO:0007507 IMP heart development
GO:0007595 IMP lactation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0009880 IMP embryonic pattern specification
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0016477 ISS cell migration
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0021551 IMP central nervous system morphogenesis
GO:0021889 IMP olfactory bulb interneuron differentiation
GO:0023014 IEA signal transduction by phosphorylation
GO:0030334 IMP regulation of cell migration
GO:0042523 IMP positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042803 IEA protein homodimerization activity
GO:0043066 ISS negative regulation of apoptotic process
GO:0043235 ISO receptor complex
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 ISS mitochondrial fragmentation involved in apoptotic process
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045165 IDA cell fate commitment
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046777 ISS protein autophosphorylation
GO:0060045 IMP positive regulation of cardiac muscle cell proliferation
GO:0060644 IMP mammary gland epithelial cell differentiation
GO:0060749 IMP mammary gland alveolus development
GO:0061026 IMP cardiac muscle tissue regeneration
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:2000366 IMP positive regulation of STAT protein import into nucleus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013847 egfra protein_coding Danio_rerio
ENSDARG00000090408 ERBB4 (2 of 2) protein_coding Danio_rerio
ENSG00000178568 ERBB4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 protein_coding Homo_sapiens

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