ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: egl-9 family hypoxia-inducible factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000366641 EGLN1-001 ENSG00000135766 9606 - 1:231363751-231425044 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000366641
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000366641 2.813±0.92 3.893±3.55 4.379±0.00 4.758±2.88

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0016491 IEA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018401 IDA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019899 ISS enzyme binding
GO:0030821 ISS negative regulation of cAMP catabolic process
GO:0031418 IEA L-ascorbic acid binding
GO:0031543 TAS peptidyl-proline dioxygenase activity
GO:0031545 IDA peptidyl-proline 4-dioxygenase activity
GO:0032364 IDA oxygen homeostasis
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045765 ISS regulation of angiogenesis
GO:0051344 ISS negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0055008 IEA cardiac muscle tissue morphogenesis
GO:0055114 IEA oxidation-reduction process
GO:0060347 IEA heart trabecula formation
GO:0060412 IEA ventricular septum morphogenesis
GO:0060711 IEA labyrinthine layer development
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia
GO:0071731 IDA response to nitric oxide

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034469 Egln1-201 protein_coding Mus_musculus 0 1072
ENSDART00000024296 egln1b-001 protein_coding Danio_rerio 0 472
ENSDART00000140204 egln1b-001 protein_coding Danio_rerio 0 228

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