ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SRY (sex determining region Y)-box 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005513 SOX8 9606 + 16:981808-986979 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293894 SOX8-001 981808-986979 protein_coding
  ENST00000566034 SOX8-002 982086-986978 retained_intron

Homo sapiens Ensembl GRCh38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000293894ENST00000566034
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000293894 0.081±0.00 0.919±1.03 1.897±0.00 0.078±0.00 0.126±0.07
ENST00000566034 0.027±0.00 0.120±0.11 0.529±0.00 0.099±0.00 0.145±0.19

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000979 ISS RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001649 ISS osteoblast differentiation
GO:0001701 ISS in utero embryonic development
GO:0001755 ISS neural crest cell migration
GO:0003677 NAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 IC nucleus
GO:0005737 ISS cytoplasm
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007165 ISS signal transduction
GO:0007283 ISS spermatogenesis
GO:0007422 ISS peripheral nervous system development
GO:0008134 IEA transcription factor binding
GO:0008584 ISS male gonad development
GO:0010628 IEA positive regulation of gene expression
GO:0010817 ISS regulation of hormone levels
GO:0014015 ISS positive regulation of gliogenesis
GO:0033690 ISS positive regulation of osteoblast proliferation
GO:0035914 IEA skeletal muscle cell differentiation
GO:0043066 ISS negative regulation of apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044798 IEA nuclear transcription factor complex
GO:0045165 ISS cell fate commitment
GO:0045444 ISS fat cell differentiation
GO:0045662 ISS negative regulation of myoblast differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046533 IEA negative regulation of photoreceptor cell differentiation
GO:0046982 IEA protein heterodimerization activity
GO:0048469 IEA cell maturation
GO:0048484 ISS enteric nervous system development
GO:0048709 ISS oligodendrocyte differentiation
GO:0060009 ISS Sertoli cell development
GO:0060018 IEA astrocyte fate commitment
GO:0060041 ISS retina development in camera-type eye
GO:0060221 ISS retinal rod cell differentiation
GO:0060612 ISS adipose tissue development
GO:0061138 ISS morphogenesis of a branching epithelium
GO:0072034 ISS renal vesicle induction
GO:0072197 ISS ureter morphogenesis
GO:0072289 ISS metanephric nephron tubule formation
GO:0090184 ISS positive regulation of kidney development
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037782 sox8b protein_coding Danio_rerio
ENSDARG00000043923 sox9b protein_coding Danio_rerio
ENSMUSG00000024176 Sox8 protein_coding Mus_musculus

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