ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: mitogen-activated protein kinase kinase kinase 14
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000006062 MAP3K14 9606 - 17:45263121-45317040 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344686 MAP3K14-001 45263121-45317040 protein_coding
  ENST00000376926 MAP3K14-201 45263128-45290976 protein_coding
  ENST00000586644 MAP3K14-004 45270752-45273602 retained_intron
  ENST00000592267 MAP3K14-003 45263135-45273966 retained_intron
  ENST00000617331 MAP3K14-005 45281638-45317017 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000344686ENST00000376926ENST00000592267ENST00000617331
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000344686 0.672±0.00 3.108±1.92 2.093±0.00 1.671±0.00 1.550±0.78
ENST00000376926 N/A N/A N/A N/A 0.421±0.36
ENST00000592267 3.912±0.66 0.841±0.00 N/A 2.484±0.00 0.594±0.29
ENST00000617331 N/A N/A N/A N/A 3.030±1.20

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002SG CIL_0002SG_0001 CGP
CIL_0002S1 CIL_0002S1_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0004672 IDA:IEA protein kinase activity
GO:0004704 ISS NF-kappaB-inducing kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006955 ISS immune response
GO:0007249 ISS I-kappaB kinase/NF-kappaB signaling
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031295 TAS T cell costimulation
GO:0038061 IEA NIK/NF-kappaB signaling
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071260 IEP cellular response to mechanical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056582 MAP3K14 (1 of 2) protein_coding Danio_rerio
ENSDARG00000074060 MAP3K14 (2 of 2) protein_coding Danio_rerio
ENSMUSG00000020941 Map3k14 protein_coding Mus_musculus

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