ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: malate dehydrogenase 1, NAD (soluble)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000014641 MDH1 9606 + 2:63588609-63607197 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000233114 MDH1-001 63588609-63607197 protein_coding
  ENST00000409476 MDH1-011 63588973-63607091 protein_coding
  ENST00000409908 MDH1-010 63588958-63607091 protein_coding
  ENST00000421012 MDH1-009 63589325-63604810 nonsense_mediated_decay
  ENST00000432309 MDH1-003 63589151-63604810 protein_coding
  ENST00000436321 MDH1-004 63588982-63599288 protein_coding
  ENST00000442225 MDH1-006 63588963-63595519 protein_coding
  ENST00000454035 MDH1-007 63588997-63597538 protein_coding
  ENST00000462944 MDH1-005 63588985-63590974 processed_transcript
  ENST00000472098 MDH1-002 63588998-63598186 retained_intron
  ENST00000484538 MDH1-013 63597548-63600052 retained_intron
  ENST00000485155 MDH1-008 63588979-63594990 retained_intron
  ENST00000485781 MDH1-012 63588609-63597657 retained_intron
  ENST00000495083 MDH1-014 63605810-63607194 retained_intron
  ENST00000539945 MDH1-201 63589151-63607194 protein_coding
  ENST00000544381 MDH1-202 63589151-63607194 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000233114ENST00000409476ENST00000409908ENST00000421012ENST00000432309ENST00000436321ENST00000495083ENST00000539945
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000233114 5.591±0.92 20.672±4.32 N/A 16.541±0.00 35.948±19.60
ENST00000409476 28.638±1.10 35.994±8.02 17.407±0.00 66.708±0.00 30.298±12.35
ENST00000409908 29.971±13.00 37.786±9.01 22.237±0.00 N/A 26.165±0.00
ENST00000421012 N/A 34.111±0.00 N/A N/A N/A
ENST00000432309 N/A N/A N/A N/A 0.913±0.00
ENST00000436321 20.460±0.00 32.506±5.43 N/A 48.359±0.00 43.403±0.00
ENST00000495083 42.366±4.26 N/A 40.068±0.00 N/A 26.191±0.00
ENST00000539945 N/A 19.472±7.77 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000100 CIL_000100_0002 CGP
CIL_000105 CIL_000105_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0004470 TAS malic enzyme activity
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005975 TAS:IEA carbohydrate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006094 TAS gluconeogenesis
GO:0006099 IEA tricarboxylic acid cycle
GO:0006107 IEA oxaloacetate metabolic process
GO:0006108 IEA malate metabolic process
GO:0006734 IEA NADH metabolic process
GO:0016491 IEA oxidoreductase activity
GO:0016615 IEA malate dehydrogenase activity
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019674 IEA NAD metabolic process
GO:0030060 TAS:IEA L-malate dehydrogenase activity
GO:0044262 IEA cellular carbohydrate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0047860 IEA diiodophenylpyruvate reductase activity
GO:0051287 IEA NAD binding
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017772 mdh1aa protein_coding Danio_rerio
ENSMUSG00000020321 Mdh1 protein_coding Mus_musculus

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