ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000051382 PIK3CB 9606 - 3:138652699-138834938 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000289153 PIK3CB-201 138652699-138759359 protein_coding
  ENST00000461451 PIK3CB-003 138755849-138834938 protein_coding
  ENST00000462294 PIK3CB-014 138714660-138742781 protein_coding
  ENST00000462898 PIK3CB-002 138654068-138834917 nonsense_mediated_decay
  ENST00000465581 PIK3CB-008 138759175-138770555 protein_coding
  ENST00000469284 PIK3CB-005 138654020-138712304 nonsense_mediated_decay
  ENST00000473435 PIK3CB-009 138681984-138712253 nonsense_mediated_decay
  ENST00000477593 PIK3CB-001 138654018-138834752 protein_coding
  ENST00000481749 PIK3CB-006 138655088-138707621 retained_intron
  ENST00000483968 PIK3CB-007 138755757-138834833 protein_coding
  ENST00000485060 PIK3CB-010 138683678-138685126 retained_intron
  ENST00000487552 PIK3CB-012 138657283-138663933 retained_intron
  ENST00000493568 PIK3CB-004 138655150-138714715 protein_coding
  ENST00000544716 PIK3CB-202 138654022-138714486 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000289153ENST00000461451ENST00000462898ENST00000469284ENST00000477593ENST00000481749ENST00000493568
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000289153 N/A 1.081±0.11 N/A N/A 0.723±0.35
ENST00000461451 N/A N/A N/A N/A 3.858±1.24
ENST00000462898 N/A 2.327±0.41 N/A 1.882±0.00 1.155±0.42
ENST00000469284 2.460±1.67 N/A 3.269±0.00 N/A 1.056±0.23
ENST00000477593 0.242±0.00 5.664±1.10 N/A 4.779±0.00 3.819±3.88
ENST00000481749 N/A N/A N/A N/A 1.600±0.54
ENST00000493568 N/A 2.543±0.62 N/A 3.024±0.00 2.029±0.45

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001952 IEA regulation of cell-matrix adhesion
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0005886 IBA plasma membrane
GO:0005942 IBA phosphatidylinositol 3-kinase complex
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006914 IEA autophagy
GO:0006935 TAS chemotaxis
GO:0007156 IEA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007165 NAS signal transduction
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010508 TAS positive regulation of autophagy
GO:0014065 TAS phosphatidylinositol 3-kinase signaling
GO:0016301 IEA kinase activity
GO:0016303 IBA 1-phosphatidylinositol-3-kinase activity
GO:0016477 TAS cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0030168 TAS platelet activation
GO:0035004 TAS phosphatidylinositol 3-kinase activity
GO:0035005 IBA 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0036092 IEA phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040016 IEA embryonic cleavage
GO:0043560 IEA insulin receptor substrate binding
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0046854 IEA phosphatidylinositol phosphorylation
GO:0046934 IBA phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 IEA:TAS phosphatidylinositol-mediated signaling
GO:0050852 TAS T cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0070527 TAS platelet aggregation
GO:2000369 TAS regulation of clathrin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075253 pik3cb protein_coding Danio_rerio
ENSMUSG00000032462 Pik3cb protein_coding Mus_musculus

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