ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: tyrosine kinase, non-receptor, 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000061938 TNK2 9606 - 3:195863364-195911945 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333602 TNK2-002 195863364-195909084 protein_coding
  ENST00000381916 TNK2-005 195863364-195895561 protein_coding
  ENST00000411741 TNK2-019 195868588-195876736 protein_coding
  ENST00000416152 TNK2-010 195863364-195872382 protein_coding
  ENST00000420716 TNK2-011 195863365-195869690 retained_intron
  ENST00000424563 TNK2-020 195868356-195876695 protein_coding
  ENST00000427576 TNK2-012 195886974-195896783 protein_coding
  ENST00000428187 TNK2-007 195863365-195892784 protein_coding
  ENST00000430929 TNK2-017 195879083-195885033 nonsense_mediated_decay
  ENST00000433111 TNK2-014 195884975-195894730 protein_coding
  ENST00000438207 TNK2-016 195878511-195888584 protein_coding
  ENST00000439230 TNK2-004 195868223-195895933 nonsense_mediated_decay
  ENST00000447060 TNK2-015 195884845-195892601 nonsense_mediated_decay
  ENST00000464041 TNK2-006 195868217-195892775 retained_intron
  ENST00000468680 TNK2-022 195870173-195872806 retained_intron
  ENST00000468819 TNK2-003 195879122-195911945 processed_transcript
  ENST00000478623 TNK2-021 195868506-195876650 processed_transcript
  ENST00000478715 TNK2-023 195869459-195872403 retained_intron
  ENST00000481865 TNK2-009 195868225-195886273 retained_intron
  ENST00000486523 TNK2-013 195872280-195896161 processed_transcript
  ENST00000489628 TNK2-018 195868630-195879486 retained_intron
  ENST00000495247 TNK2-024 195868084-195870168 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000333602ENST00000416152ENST00000428187ENST00000438207ENST00000481865
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000333602 N/A 2.688±1.58 N/A N/A 2.946±1.21
ENST00000416152 37.966±11.30 N/A 38.601±0.00 N/A 6.802±2.67
ENST00000428187 N/A 2.830±1.63 N/A 5.769±0.00 3.128±1.01
ENST00000438207 N/A 8.842±1.85 N/A N/A N/A
ENST00000481865 N/A 0.447±0.00 N/A N/A 1.369±0.95

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008QR CIL_0008QR_0001 VISTA
CIL_0003O7 CIL_0003O7_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005095 TAS GTPase inhibitor activity
GO:0005154 IDA epidermal growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 ISS endosome
GO:0005886 IDA plasma membrane
GO:0005905 IDA coated pit
GO:0006468 IEA protein phosphorylation
GO:0006897 IEA endocytosis
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0016020 IDA membrane
GO:0016310 IDA phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030054 IEA cell junction
GO:0030136 IDA clathrin-coated vesicle
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0043025 IEA neuronal cell body
GO:0043086 TAS negative regulation of catalytic activity
GO:0046872 IEA metal ion binding
GO:0050699 ISS WW domain binding
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0070436 IDA Grb2-EGFR complex
GO:2000369 IDA regulation of clathrin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090646 tnk2a protein_coding Danio_rerio
ENSMUSG00000022791 Tnk2 protein_coding Mus_musculus

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