ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: mitogen-activated protein kinase kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000065559 MAP2K4 9606 + 17:12020824-12143830 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000353533 MAP2K4-001 12020824-12143823 protein_coding
  ENST00000415385 MAP2K4-002 12020834-12143830 protein_coding
  ENST00000536413 MAP2K4-005 12124299-12143730 retained_intron
  ENST00000538465 MAP2K4-008 12020976-12141621 nonsense_mediated_decay
  ENST00000579089 MAP2K4-009 12069756-12125350 processed_transcript
  ENST00000581941 MAP2K4-003 12069657-12125318 processed_transcript
  ENST00000582183 MAP2K4-010 12020829-12113318 nonsense_mediated_decay
  ENST00000582377 MAP2K4-004 12095602-12110809 retained_intron
  ENST00000582897 MAP2K4-006 12026887-12095694 processed_transcript
  ENST00000585076 MAP2K4-007 12113040-12129282 retained_intron
  ENST00000602305 MAP2K4-013 12020870-12141282 nonsense_mediated_decay
  ENST00000602375 MAP2K4-012 12020870-12141282 nonsense_mediated_decay
  ENST00000602537 MAP2K4-015 12020887-12141260 nonsense_mediated_decay
  ENST00000602686 MAP2K4-014 12020887-12141260 nonsense_mediated_decay
  ENST00000602811 MAP2K4-011 12020870-12141282 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000353533ENST00000415385ENST00000536413ENST00000602375
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000353533 2.148±1.62 5.508±0.00 3.212±2.43
ENST00000415385 N/A N/A 0.054±0.00
ENST00000536413 N/A N/A 0.778±0.11
ENST00000602375 N/A N/A 0.143±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008WK CIL_0008WK_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0007254 TAS JNK cascade
GO:0007257 IEA activation of JUN kinase activity
GO:0008545 IEA JUN kinase kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030424 IEA axon
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032839 IEA dendrite cytoplasm
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065 IEA positive regulation of apoptotic process
GO:0043204 IEA perikaryon
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045087 TAS innate immune response
GO:0045740 IEA positive regulation of DNA replication
GO:0051403 TAS stress-activated MAPK cascade
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0071260 IEP cellular response to mechanical stimulus
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063583 map2k4a protein_coding Danio_rerio
ENSDARG00000077177 map2k4b protein_coding Danio_rerio
ENSMUSG00000033352 Map2k4 protein_coding Mus_musculus

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