ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000086758 HUWE1 9606 - X:53532096-53686729 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000218328 HUWE1-007 53584211-53686728 processed_transcript
  ENST00000262854 HUWE1-201 53532098-53686729 protein_coding
  ENST00000342160 HUWE1-001 53532096-53684169 protein_coding
  ENST00000426907 HUWE1-005 53532096-53549505 protein_coding
  ENST00000446750 HUWE1-010 53647441-53684169 protein_coding
  ENST00000463852 HUWE1-013 53539657-53542872 retained_intron
  ENST00000468322 HUWE1-012 53542443-53547809 nonsense_mediated_decay
  ENST00000471676 HUWE1-008 53630873-53631752 retained_intron
  ENST00000474288 HUWE1-011 53543710-53548052 retained_intron
  ENST00000474971 HUWE1-003 53535927-53536651 retained_intron
  ENST00000480438 HUWE1-014 53537264-53538467 retained_intron
  ENST00000488459 HUWE1-004 53533542-53534659 retained_intron
  ENST00000489876 HUWE1-006 53615770-53625478 retained_intron
  ENST00000612484 HUWE1-002 53532096-53654107 protein_coding
  ENST00000622887 HUWE1-009 53624620-53628526 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000218328ENST00000262854ENST00000342160ENST00000426907ENST00000488459ENST00000612484
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000218328 N/A 11.693±0.49 N/A N/A 9.828±4.97
ENST00000262854 1.769±0.00 4.026±1.41 N/A N/A 2.385±0.00
ENST00000342160 2.000±0.00 7.796±2.81 N/A 4.649±0.00 4.523±2.76
ENST00000426907 19.964±0.00 N/A 3.579±0.00 N/A 8.829±1.77
ENST00000488459 N/A N/A 17.836±0.00 N/A N/A
ENST00000612484 N/A 12.683±6.17 N/A 7.083±0.00 3.703±1.16

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0003677 ISS DNA binding
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0006284 IMP base-excision repair
GO:0006513 IDA protein monoubiquitination
GO:0016020 IDA membrane
GO:0016574 IDA histone ubiquitination
GO:0016874 IEA ligase activity
GO:0030154 IEA cell differentiation
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016782 huwe1 protein_coding Danio_rerio
ENSMUSG00000025261 Huwe1 protein_coding Mus_musculus

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