ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: dynamin 1-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087470 DNM1L 9606 + 12:32679200-32745650 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000266481 DNM1L-005 32679303-32744350 protein_coding
  ENST00000358214 DNM1L-004 32679292-32744428 protein_coding
  ENST00000381000 DNM1L-010 32679323-32745549 protein_coding
  ENST00000413295 DNM1L-007 32679320-32731383 nonsense_mediated_decay
  ENST00000414834 DNM1L-201 32679200-32745650 protein_coding
  ENST00000434676 DNM1L-006 32679320-32731061 nonsense_mediated_decay
  ENST00000452533 DNM1L-001 32679200-32745552 protein_coding
  ENST00000546649 DNM1L-009 32679320-32743656 nonsense_mediated_decay
  ENST00000546757 DNM1L-011 32701415-32744087 nonsense_mediated_decay
  ENST00000547078 DNM1L-023 32731486-32738296 nonsense_mediated_decay
  ENST00000547312 DNM1L-008 32679320-32743581 protein_coding
  ENST00000547548 DNM1L-021 32713247-32722772 retained_intron
  ENST00000547640 DNM1L-028 32739845-32742684 retained_intron
  ENST00000547719 DNM1L-020 32706867-32708206 retained_intron
  ENST00000547932 DNM1L-017 32679320-32718718 processed_transcript
  ENST00000548151 DNM1L-025 32733453-32737306 retained_intron
  ENST00000548671 DNM1L-022 32679301-32713346 processed_transcript
  ENST00000548750 DNM1L-018 32679336-32720795 protein_coding
  ENST00000549157 DNM1L-027 32737977-32740467 retained_intron
  ENST00000549701 DNM1L-003 32679290-32743612 protein_coding
  ENST00000549926 DNM1L-019 32679708-32713324 processed_transcript
  ENST00000550011 DNM1L-012 32679316-32706102 retained_intron
  ENST00000550093 DNM1L-024 32731469-32738151 retained_intron
  ENST00000550154 DNM1L-016 32679320-32713330 protein_coding
  ENST00000551076 DNM1L-013 32679316-32711003 processed_transcript
  ENST00000551476 DNM1L-015 32679320-32713319 protein_coding
  ENST00000551643 DNM1L-014 32679320-32708224 nonsense_mediated_decay
  ENST00000552743 DNM1L-026 32733566-32738171 retained_intron
  ENST00000553031 DNM1L-029 32740154-32743583 retained_intron
  ENST00000553257 DNM1L-002 32679287-32743782 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000266481ENST00000381000ENST00000414834ENST00000452533ENST00000546649ENST00000546757ENST00000547312ENST00000549701ENST00000553031
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000266481 N/A 6.637±2.28 7.124±0.00 4.177±2.00
ENST00000381000 N/A 2.294±0.23 8.363±0.00 3.986±1.80
ENST00000414834 N/A N/A N/A 3.085±0.57
ENST00000452533 N/A 8.302±4.01 4.500±0.00 6.997±3.75
ENST00000546649 4.789±0.00 N/A N/A N/A
ENST00000546757 N/A 3.137±0.28 N/A N/A
ENST00000547312 N/A 6.970±2.36 N/A 5.435±1.72
ENST00000549701 N/A 5.777±1.55 10.645±0.00 6.374±3.08
ENST00000553031 21.554±0.49 N/A N/A N/A

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000266 IMP mitochondrial fission
GO:0001836 IMP release of cytochrome c from mitochondria
GO:0003374 IDA dynamin polymerization involved in mitochondrial fission
GO:0003924 IDA:IEA GTPase activity
GO:0005515 IPI protein binding
GO:0005525 IEA GTP binding
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IDA mitochondrial outer membrane
GO:0005777 IDA peroxisome
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005874 IDA microtubule
GO:0005905 IEA coated pit
GO:0006184 IDA GTP catabolic process
GO:0006897 IEA endocytosis
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0008289 IEA lipid binding
GO:0010821 IMP regulation of mitochondrion organization
GO:0016020 IDA membrane
GO:0016559 IDA peroxisome fission
GO:0030054 IEA cell junction
GO:0031410 IEA cytoplasmic vesicle
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032459 IDA regulation of protein oligomerization
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043065 IMP positive regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043234 IDA protein complex
GO:0043653 IMP mitochondrial fragmentation involved in apoptotic process
GO:0045202 IEA synapse
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050714 IDA positive regulation of protein secretion
GO:0051289 IDA protein homotetramerization
GO:0061025 IDA membrane fusion
GO:0070266 IMP necroptotic process
GO:0070584 IMP mitochondrion morphogenesis
GO:0070585 IEA protein localization to mitochondrion
GO:0090141 TAS positive regulation of mitochondrial fission
GO:0090149 IDA membrane fission involved in mitochondrial fission
GO:0090200 IMP positive regulation of release of cytochrome c from mitochondria
GO:1900063 IMP regulation of peroxisome organization
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015006 dnm1l protein_coding Danio_rerio
ENSMUSG00000022789 Dnm1l protein_coding Mus_musculus

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