ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Rho GTPase activating protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000089820 ARHGAP4 9606 - X:153907367-153934999 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000350060 ARHGAP4-003 153907377-153926244 protein_coding
  ENST00000370016 ARHGAP4-011 153907454-153926244 protein_coding
  ENST00000370028 ARHGAP4-001 153907376-153926260 protein_coding
  ENST00000393721 ARHGAP4-024 153907367-153926254 protein_coding
  ENST00000404127 ARHGAP4-014 153907469-153926305 nonsense_mediated_decay
  ENST00000418750 ARHGAP4-020 153918940-153921404 protein_coding
  ENST00000420383 ARHGAP4-002 153907377-153926244 nonsense_mediated_decay
  ENST00000422091 ARHGAP4-019 153920715-153926860 protein_coding
  ENST00000422918 ARHGAP4-005 153913228-153920631 protein_coding
  ENST00000442172 ARHGAP4-010 153909741-153912785 protein_coding
  ENST00000442262 ARHGAP4-017 153920708-153928419 protein_coding
  ENST00000454164 ARHGAP4-009 153909468-153911101 protein_coding
  ENST00000460782 ARHGAP4-021 153920412-153921400 retained_intron
  ENST00000461052 ARHGAP4-015 153918842-153926757 protein_coding
  ENST00000461739 ARHGAP4-007 153909819-153910519 retained_intron
  ENST00000463905 ARHGAP4-023 153913524-153914253 retained_intron
  ENST00000466928 ARHGAP4-006 153907439-153909658 retained_intron
  ENST00000467421 ARHGAP4-008 153909508-153910871 processed_transcript
  ENST00000470209 ARHGAP4-012 153907454-153926244 retained_intron
  ENST00000470979 ARHGAP4-018 153920739-153928354 processed_transcript
  ENST00000488269 ARHGAP4-004 153918962-153922248 protein_coding
  ENST00000494302 ARHGAP4-013 153907454-153926244 retained_intron
  ENST00000494397 ARHGAP4-016 153907415-153912737 retained_intron
  ENST00000494813 ARHGAP4-022 153913210-153934999 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000350060ENST00000404127ENST00000422918ENST00000494813
Transcript ID HAoEC HUVEC
ENST00000350060 2.176±0.00 6.651±5.75
ENST00000404127 2.075±0.00 0.181±0.05
ENST00000422918 N/A 1.023±0.00
ENST00000494813 N/A 0.580±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0001US CIL_0001US_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005100 IEA Rho GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005874 IEA microtubule
GO:0007010 TAS cytoskeleton organization
GO:0007165 IEA signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007266 TAS Rho protein signal transduction
GO:0007399 IEA nervous system development
GO:0009967 TAS positive regulation of signal transduction
GO:0010764 IEA negative regulation of fibroblast migration
GO:0030426 IEA growth cone
GO:0030517 IEA negative regulation of axon extension
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015003 arhgap4b protein_coding Danio_rerio
ENSDARG00000039265 arhgap4a protein_coding Danio_rerio
ENSMUSG00000031389 Arhgap4 protein_coding Mus_musculus

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