ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: NLR family, pyrin domain containing 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091592 NLRP1 9606 - 17:5499427-5619424 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262467 NLRP1-001 5501385-5584531 protein_coding
  ENST00000269280 NLRP1-010 5514127-5584448 protein_coding
  ENST00000345221 NLRP1-201 5514754-5584512 protein_coding
  ENST00000354411 NLRP1-012 5514754-5583957 protein_coding
  ENST00000544378 NLRP1-002 5499427-5584509 nonsense_mediated_decay
  ENST00000568641 NLRP1-004 5499439-5501145 processed_transcript
  ENST00000571307 NLRP1-007 5529895-5584512 processed_transcript
  ENST00000571451 NLRP1-008 5514122-5584479 nonsense_mediated_decay
  ENST00000572143 NLRP1-013 5584017-5619424 processed_transcript
  ENST00000572272 NLRP1-011 5514754-5583957 protein_coding
  ENST00000574406 NLRP1-003 5499428-5502963 processed_transcript
  ENST00000574512 NLRP1-005 5502292-5518565 retained_intron
  ENST00000576905 NLRP1-014 5583851-5619424 protein_coding
  ENST00000577119 NLRP1-009 5514754-5583957 protein_coding
  ENST00000613500 NLRP1-202 5501814-5584512 protein_coding
  ENST00000617618 NLRP1-203 5514754-5584512 protein_coding
  ENST00000619223 NLRP1-204 5514754-5584512 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000262467ENST00000269280ENST00000354411ENST00000544378ENST00000568641ENST00000571451ENST00000572143ENST00000572272ENST00000577119ENST00000617618ENST00000619223
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000262467 N/A 3.522±1.26 10.140±0.00 N/A 3.639±2.28
ENST00000269280 3.525±0.00 4.479±0.98 32.857±0.00 N/A 2.520±0.53
ENST00000354411 N/A N/A N/A N/A 1.499±0.00
ENST00000544378 N/A 2.442±0.45 N/A 1.055±0.00 N/A
ENST00000568641 10.082±0.70 33.355±3.67 38.039±0.00 4.044±0.00 3.983±0.00
ENST00000571451 N/A 2.698±0.79 N/A 2.616±0.00 6.917±6.71
ENST00000572143 N/A N/A N/A N/A 24.677±0.00
ENST00000572272 N/A N/A N/A 1.196±0.00 10.617±2.39
ENST00000577119 N/A N/A N/A N/A 0.002±0.00
ENST00000617618 N/A 1.609±0.51 N/A N/A 3.087±1.03
ENST00000619223 N/A N/A N/A N/A 3.108±0.56

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002G8 CIL_0002G8_0001 CGP
CIL_0000N1 CIL_0000N1_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA ATP binding
GO:0005622 IC intracellular
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0006919 NAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899 IPI enzyme binding
GO:0019904 IPI protein domain specific binding
GO:0032495 ISS response to muramyl dipeptide
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742 ISS defense response to bacterium
GO:0042981 IEA regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0050718 ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IC regulation of inflammatory response
GO:0051402 IDA neuron apoptotic process
GO:0072558 IDA NLRP1 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000069830 Nlrp1a protein_coding Mus_musculus
ENSMUSG00000070390 Nlrp1b protein_coding Mus_musculus

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