ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: excision repair cross-complementation group 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104884 ERCC2 9606 - 19:45349837-45370918 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000391941 ERCC2-005 45352209-45370918 protein_coding
  ENST00000391942 ERCC2-007 45351595-45361931 retained_intron
  ENST00000391944 ERCC2-201 45351391-45370587 protein_coding
  ENST00000391945 ERCC2-001 45349837-45370618 protein_coding
  ENST00000485403 ERCC2-006 45358759-45370384 protein_coding
  ENST00000586131 ERCC2-002 45363986-45370533 protein_coding
  ENST00000586441 ERCC2-010 45364236-45370555 retained_intron
  ENST00000586737 ERCC2-009 45364091-45370555 retained_intron
  ENST00000586856 ERCC2-003 45365042-45370528 protein_coding
  ENST00000587376 ERCC2-004 45353242-45364057 nonsense_mediated_decay
  ENST00000588652 ERCC2-008 45351595-45358938 retained_intron
  ENST00000591309 ERCC2-011 45364037-45370557 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000391941ENST00000391942ENST00000391944ENST00000391945ENST00000485403ENST00000586131ENST00000587376ENST00000588652
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000391941 N/A N/A N/A N/A 5.905±1.12
ENST00000391942 15.276±4.13 19.021±0.05 13.312±0.00 N/A 6.228±4.61
ENST00000391944 N/A 16.040±7.69 N/A 11.389±0.00 6.598±5.22
ENST00000391945 7.935±3.20 24.843±11.99 1.978±0.00 14.107±0.00 8.227±6.85
ENST00000485403 N/A 3.370±0.00 N/A N/A 0.108±0.00
ENST00000586131 N/A N/A N/A N/A 4.837±4.47
ENST00000587376 N/A 36.951±2.30 N/A N/A N/A
ENST00000588652 N/A N/A N/A N/A 0.187±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000439 IEA core TFIIH complex
GO:0000718 TAS nucleotide-excision repair, DNA damage removal
GO:0001666 IEA response to hypoxia
GO:0001701 IEA in utero embryonic development
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0004003 IEA ATP-dependent DNA helicase activity
GO:0004672 IDA protein kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005675 TAS holo TFIIH complex
GO:0005737 IDA cytoplasm
GO:0005819 IDA spindle
GO:0006139 IEA nucleobase-containing compound metabolic process
GO:0006200 IEA ATP catabolic process
GO:0006281 TAS DNA repair
GO:0006283 IDA transcription-coupled nucleotide-excision repair
GO:0006289 NAS nucleotide-excision repair
GO:0006360 TAS transcription from RNA polymerase I promoter
GO:0006361 TAS transcription initiation from RNA polymerase I promoter
GO:0006362 TAS transcription elongation from RNA polymerase I promoter
GO:0006363 TAS termination of RNA polymerase I transcription
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006368 TAS transcription elongation from RNA polymerase II promoter
GO:0006370 TAS 7-methylguanosine mRNA capping
GO:0006468 IDA protein phosphorylation
GO:0006915 IMP apoptotic process
GO:0006979 IMP response to oxidative stress
GO:0007059 IMP chromosome segregation
GO:0007568 IEA aging
GO:0008022 IPI protein C-terminus binding
GO:0008026 IEA ATP-dependent helicase activity
GO:0008094 TAS DNA-dependent ATPase activity
GO:0008283 IEA cell proliferation
GO:0008353 IDA RNA polymerase II carboxy-terminal domain kinase activity
GO:0009411 IEA response to UV
GO:0009650 IGI UV protection
GO:0009791 IEA post-embryonic development
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016818 IEA hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0019907 IDA cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0021510 IEA spinal cord development
GO:0022405 IEA hair cycle process
GO:0030198 IEA extracellular matrix organization
GO:0030282 IEA bone mineralization
GO:0032289 IEA central nervous system myelin formation
GO:0032508 IEA DNA duplex unwinding
GO:0033683 IMP nucleotide-excision repair, DNA incision
GO:0035264 IEA multicellular organism growth
GO:0035315 IMP hair cell differentiation
GO:0040016 IEA embryonic cleavage
GO:0043139 IDA 5'-3' DNA helicase activity
GO:0043249 IEA erythrocyte maturation
GO:0043388 IEA positive regulation of DNA binding
GO:0043588 IEA skin development
GO:0044281 TAS small molecule metabolic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0047485 IPI protein N-terminus binding
GO:0048820 IEA hair follicle maturation
GO:0050434 TAS positive regulation of viral transcription
GO:0051539 IEA 4 iron, 4 sulfur cluster binding
GO:0060218 IEA hematopoietic stem cell differentiation
GO:0071817 IDA MMXD complex
GO:1901990 IMP regulation of mitotic cell cycle phase transition

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021985 ercc2 protein_coding Danio_rerio
ENSMUSG00000030400 Ercc2 protein_coding Mus_musculus

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