ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: amyloid beta (A4) precursor-like protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105290 APLP1 9606 + 19:35867899-35879791 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000221891 APLP1-002 35868445-35879788 protein_coding
  ENST00000537454 APLP1-001 35867899-35879526 protein_coding
  ENST00000586861 APLP1-003 35869473-35879493 protein_coding
  ENST00000587274 APLP1-009 35874508-35879751 protein_coding
  ENST00000588808 APLP1-005 35873646-35879174 protein_coding
  ENST00000589298 APLP1-007 35874504-35878544 processed_transcript
  ENST00000589743 APLP1-008 35870184-35871996 protein_coding
  ENST00000590561 APLP1-004 35868563-35879788 nonsense_mediated_decay
  ENST00000590926 APLP1-006 35878525-35879190 retained_intron
  ENST00000591165 APLP1-012 35879227-35879791 processed_transcript
  ENST00000592316 APLP1-011 35870454-35874620 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000221891ENST00000586861ENST00000587274ENST00000588808ENST00000589298ENST00000589743ENST00000590561ENST00000590926ENST00000591165ENST00000592316
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000221891 N/A 0.198±0.17 N/A N/A 0.600±0.61
ENST00000586861 0.381±0.00 2.344±2.18 N/A N/A 0.789±0.65
ENST00000587274 0.699±0.00 0.626±0.01 N/A 2.079±0.00 1.202±0.00
ENST00000588808 N/A 1.486±0.12 N/A N/A 1.252±0.45
ENST00000589298 N/A 2.087±0.41 N/A N/A N/A
ENST00000589743 1.703±0.00 N/A N/A N/A 0.675±0.58
ENST00000590561 0.382±0.13 2.746±1.66 N/A N/A 1.734±1.40
ENST00000590926 N/A N/A N/A N/A 2.045±0.00
ENST00000591165 3.653±1.19 9.362±9.39 0.582±0.00 N/A 2.611±0.56
ENST00000592316 N/A 0.459±0.01 0.145±0.00 N/A 0.657±0.28

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005604 TAS basement membrane
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006378 IEA mRNA polyadenylation
GO:0006417 IEA regulation of translation
GO:0006897 IEA endocytosis
GO:0006915 IEA apoptotic process
GO:0007155 IEA cell adhesion
GO:0007193 IC adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007399 TAS nervous system development
GO:0008201 IEA heparin binding
GO:0009887 TAS organ morphogenesis
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030198 IEA extracellular matrix organization
GO:0030818 IDA negative regulation of cAMP biosynthetic process
GO:0030900 IEA forebrain development
GO:0031694 IPI alpha-2A adrenergic receptor binding
GO:0031695 IPI alpha-2B adrenergic receptor binding
GO:0031696 IPI alpha-2C adrenergic receptor binding
GO:0042802 IPI identical protein binding
GO:0046914 IEA transition metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0071874 IDA cellular response to norepinephrine stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000006651 Aplp1 protein_coding Mus_musculus

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