ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: caspase recruitment domain family, member 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105483 CARD8 9606 - 19:48180770-48255946 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357778 CARD8-201 48230100-48232114 protein_coding
  ENST00000377461 CARD8-015 48209644-48232114 retained_intron
  ENST00000391898 CARD8-202 48208104-48241063 protein_coding
  ENST00000447740 CARD8-203 48208104-48249847 protein_coding
  ENST00000517510 CARD8-016 48203632-48255898 nonsense_mediated_decay
  ENST00000517778 CARD8-012 48233846-48249614 processed_transcript
  ENST00000518450 CARD8-017 48203146-48218953 nonsense_mediated_decay
  ENST00000518596 CARD8-011 48233821-48249828 retained_intron
  ENST00000518622 CARD8-001 48208086-48249668 nonsense_mediated_decay
  ENST00000518979 CARD8-014 48209644-48249668 nonsense_mediated_decay
  ENST00000519302 CARD8-024 48211897-48249816 nonsense_mediated_decay
  ENST00000519332 CARD8-003 48238334-48255893 protein_coding
  ENST00000519646 CARD8-013 48211152-48249826 nonsense_mediated_decay
  ENST00000519940 CARD8-009 48211617-48255889 protein_coding
  ENST00000520007 CARD8-019 48238336-48255898 protein_coding
  ENST00000520015 CARD8-005 48211377-48249833 protein_coding
  ENST00000520153 CARD8-007 48210787-48249826 protein_coding
  ENST00000520753 CARD8-002 48210487-48255886 protein_coding
  ENST00000521092 CARD8-023 48234278-48249826 retained_intron
  ENST00000521415 CARD8-010 48211617-48241063 nonsense_mediated_decay
  ENST00000521437 CARD8-020 48238475-48255897 protein_coding
  ENST00000521613 CARD8-004 48211566-48255946 protein_coding
  ENST00000522051 CARD8-006 48210790-48249833 retained_intron
  ENST00000522068 CARD8-018 48231729-48255911 processed_transcript
  ENST00000522431 CARD8-022 48238262-48249771 protein_coding
  ENST00000522773 CARD8-008 48210787-48249810 nonsense_mediated_decay
  ENST00000522889 CARD8-021 48234472-48255871 protein_coding
  ENST00000523579 CARD8-025 48211827-48230498 nonsense_mediated_decay
  ENST00000523668 CARD8-027 48215138-48230647 retained_intron
  ENST00000523750 CARD8-026 48233410-48234464 processed_transcript
  ENST00000600800 CARD8-029 48180770-48203952 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000357778ENST00000377461ENST00000391898ENST00000447740ENST00000518622ENST00000518979ENST00000519332ENST00000519940ENST00000520007ENST00000520015ENST00000520153ENST00000520753ENST00000522051ENST00000600800
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000357778 N/A N/A N/A N/A 9.497±0.00
ENST00000377461 N/A N/A 16.285±0.00 N/A N/A
ENST00000391898 6.364±0.00 3.042±0.41 18.745±0.00 15.130±0.00 8.761±3.99
ENST00000447740 N/A N/A N/A N/A 9.350±5.44
ENST00000518622 N/A N/A 9.044±0.00 N/A 6.247±3.73
ENST00000518979 N/A N/A N/A N/A 16.746±3.42
ENST00000519332 N/A N/A N/A N/A 74.866±0.00
ENST00000519940 N/A N/A N/A N/A 6.812±2.09
ENST00000520007 N/A N/A N/A N/A 66.762±13.52
ENST00000520015 N/A N/A N/A N/A 7.977±1.71
ENST00000520153 N/A 16.132±8.88 N/A 20.556±0.00 12.556±4.55
ENST00000520753 N/A 8.023±2.05 N/A N/A N/A
ENST00000522051 N/A 15.061±2.34 N/A 16.747±0.00 12.198±8.99
ENST00000600800 N/A N/A N/A N/A 0.101±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008656 IDA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0032089 IPI NACHT domain binding
GO:0042803 IDA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0072559 IDA NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000094305 RNH1 (7 of 29) protein_coding Danio_rerio
ENSDARG00000096064 RNH1 (11 of 29) protein_coding Danio_rerio
ENSDARG00000096067 RNH1 (12 of 29) protein_coding Danio_rerio

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