ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: caspase 2, apoptosis-related cysteine peptidase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106144 CASP2 9606 + 7:143288215-143307696 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000310447 CASP2-001 143288215-143307696 protein_coding
  ENST00000350623 CASP2-003 143288451-143305071 nonsense_mediated_decay
  ENST00000392925 CASP2-005 143288395-143293226 protein_coding
  ENST00000472067 CASP2-004 143294604-143306569 retained_intron
  ENST00000481483 CASP2-006 143291618-143294481 retained_intron
  ENST00000493642 CASP2-002 143289588-143305822 processed_transcript
  ENST00000619992 CASP2-201 143288215-143307695 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000310447ENST00000472067ENST00000493642ENST00000619992
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000310447 1.892±0.00 10.109±3.35 4.414±0.00 11.518±4.22
ENST00000472067 N/A 0.581±0.00 N/A 2.905±0.94
ENST00000493642 N/A 3.125±1.16 N/A 5.000±0.75
ENST00000619992 1.305±0.00 2.364±0.57 2.700±0.00 3.882±1.91

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006VH CIL_0006VH_0001 CGP
CIL_0006VM CIL_0006VM_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001554 IEA luteolysis
GO:0003407 IEA neural retina development
GO:0004197 IDA:IEA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 IBA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006508 IEA proteolysis
GO:0006915 NAS:IEA apoptotic process
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420 IEA brain development
GO:0007568 IEA aging
GO:0008234 IEA cysteine-type peptidase activity
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016020 IEA membrane
GO:0016485 IDA protein processing
GO:0019899 ISS enzyme binding
GO:0019904 IPI protein domain specific binding
GO:0035234 IEA ectopic germ cell programmed cell death
GO:0042981 IEA regulation of apoptotic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043281 TAS regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:0097153 IEA cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 TAS apoptotic signaling pathway
GO:0097192 IBA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 TAS execution phase of apoptosis
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062052 casp2 protein_coding Danio_rerio
ENSMUSG00000029863 Casp2 protein_coding Mus_musculus

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