ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: secreted frizzled-related protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106483 SFRP4 9606 - 7:37905932-38025695 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000436072 SFRP4-001 37905932-37916915 protein_coding
  ENST00000447200 SFRP4-003 37909659-38025695 protein_coding
  ENST00000478975 SFRP4-002 37907262-37909839 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHUVECENST00000436072ENST00000447200ENST00000478975
Transcript ID BECs HAoEC HHSEC HUVEC
ENST00000436072 0.064±0.00 0.052±0.03 0.016±0.00 0.010±0.01
ENST00000447200 N/A 0.096±0.03 N/A N/A
ENST00000478975 N/A 0.116±0.09 N/A 0.080±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001944 IBA vasculature development
GO:0002092 IDA positive regulation of receptor internalization
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0007420 IBA brain development
GO:0008285 IMP negative regulation of cell proliferation
GO:0008406 IBA gonad development
GO:0009725 NAS response to hormone
GO:0009986 IDA cell surface
GO:0010628 IDA positive regulation of gene expression
GO:0016055 IEA Wnt signaling pathway
GO:0017147 IBA Wnt-protein binding
GO:0022601 NAS menstrual cycle phase
GO:0030165 IBA PDZ domain binding
GO:0042813 IBA Wnt-activated receptor activity
GO:0043065 IMP positive regulation of apoptotic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606 IDA positive regulation of epidermal cell differentiation
GO:0046329 IBA negative regulation of JNK cascade
GO:0046697 IBA decidualization
GO:0055062 IDA phosphate ion homeostasis
GO:0060056 IBA mammary gland involution
GO:0060429 IBA epithelium development
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0090263 IGI positive regulation of canonical Wnt signaling pathway
GO:1902174 IDA positive regulation of keratinocyte apoptotic process
GO:2000119 IDA negative regulation of sodium-dependent phosphate transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000021319 Sfrp4 protein_coding Mus_musculus

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