ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: GRB2-associated binding protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109458 GAB1 9606 + 4:143336762-143474568 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262994 GAB1-002 143336887-143469450 protein_coding
  ENST00000262995 GAB1-001 143336762-143474568 protein_coding
  ENST00000505913 GAB1-003 143381945-143469567 protein_coding
  ENST00000507070 GAB1-010 143439650-143459429 retained_intron
  ENST00000507334 GAB1-012 143438257-143440016 retained_intron
  ENST00000508833 GAB1-013 143440173-143466175 processed_transcript
  ENST00000509992 GAB1-006 143391510-143433716 protein_coding
  ENST00000510615 GAB1-011 143439673-143459433 retained_intron
  ENST00000511109 GAB1-014 143465997-143469639 retained_intron
  ENST00000511836 GAB1-007 143415509-143433680 nonsense_mediated_decay
  ENST00000512843 GAB1-009 143433491-143469407 protein_coding
  ENST00000514639 GAB1-008 143337178-143438041 protein_coding
  ENST00000515366 GAB1-005 143376825-143433577 protein_coding
  ENST00000515388 GAB1-004 143381948-143395720 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000262994ENST00000262995ENST00000505913ENST00000511109
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000262994 0.503±0.08 N/A 1.864±0.87
ENST00000262995 1.127±1.53 N/A 1.594±0.88
ENST00000505913 0.561±0.15 0.978±0.00 2.309±1.17
ENST00000511109 2.214±0.15 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006MQ CIL_0006MQ_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0004871 IEA signal transducer activity
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006979 IEA response to oxidative stress
GO:0007165 IEA signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007257 IEA activation of JUN kinase activity
GO:0007507 IEA heart development
GO:0008283 TAS cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008544 IEA epidermis development
GO:0030334 IEA regulation of cell migration
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045087 TAS innate immune response
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0060711 IEA labyrinthine layer development
GO:0070102 IEA interleukin-6-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037018 gab1 protein_coding Danio_rerio
ENSMUSG00000031714 Gab1 protein_coding Mus_musculus

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