ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: heat shock 70kDa protein 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109971 HSPA8 9606 - 11:123057489-123063230 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000227378 HSPA8-006 123057497-123061332 protein_coding
  ENST00000453788 HSPA8-002 123057489-123062335 protein_coding
  ENST00000524552 HSPA8-027 123057779-123059448 protein_coding
  ENST00000524590 HSPA8-024 123060593-123062032 protein_coding
  ENST00000525463 HSPA8-018 123059965-123062136 protein_coding
  ENST00000525624 HSPA8-011 123060118-123063230 protein_coding
  ENST00000526110 HSPA8-009 123057701-123061331 protein_coding
  ENST00000526686 HSPA8-028 123057879-123059097 protein_coding
  ENST00000526862 HSPA8-026 123059156-123060223 processed_transcript
  ENST00000527387 HSPA8-012 123060146-123062352 protein_coding
  ENST00000527983 HSPA8-008 123059233-123062207 retained_intron
  ENST00000528292 HSPA8-015 123059476-123062124 protein_coding
  ENST00000530391 HSPA8-022 123060607-123061833 protein_coding
  ENST00000531063 HSPA8-013 123060825-123062136 retained_intron
  ENST00000532091 HSPA8-025 123057496-123060426 retained_intron
  ENST00000532167 HSPA8-016 123059982-123062136 retained_intron
  ENST00000532182 HSPA8-021 123060165-123062022 protein_coding
  ENST00000532636 HSPA8-004 123057489-123061789 protein_coding
  ENST00000532780 HSPA8-007 123059814-123062669 retained_intron
  ENST00000533238 HSPA8-014 123058791-123062139 processed_transcript
  ENST00000533540 HSPA8-003 123057489-123062136 protein_coding
  ENST00000534319 HSPA8-010 123057498-123060386 protein_coding
  ENST00000534567 HSPA8-023 123060129-123061483 protein_coding
  ENST00000534624 HSPA8-001 123057489-123062335 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000227378ENST00000453788ENST00000526110ENST00000527983ENST00000528292ENST00000532091ENST00000533238ENST00000533540ENST00000534319
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000227378 154.900±0.00 226.627±90.91 8.164±0.00 571.386±0.00 342.582±226.49
ENST00000453788 N/A 108.940±21.24 N/A N/A 78.139±38.97
ENST00000526110 N/A N/A N/A N/A 97.914±90.70
ENST00000527983 N/A N/A N/A N/A 29.662±29.65
ENST00000528292 N/A 219.719±78.35 N/A N/A 19.541±0.00
ENST00000532091 N/A N/A N/A N/A 5.219±0.34
ENST00000533238 N/A N/A N/A N/A 483.004±329.17
ENST00000533540 519.545±88.83 252.894±54.80 18.696±0.00 198.665±0.00 155.124±78.09
ENST00000534319 296.667±106.77 134.164±27.73 20.676±0.00 N/A 147.546±53.18

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000902 IEA cell morphogenesis
GO:0000974 IDA Prp19 complex
GO:0001664 IPI G-protein coupled receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005615 IDA extracellular space
GO:0005622 NAS intracellular
GO:0005634 IDA nucleus
GO:0005681 IEA spliceosomal complex
GO:0005829 IDA cytosol
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006200 IDA ATP catabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006397 IEA mRNA processing
GO:0006457 NAS protein folding
GO:0006892 TAS post-Golgi vesicle-mediated transport
GO:0006986 NAS response to unfolded protein
GO:0007049 IEA cell cycle
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0007411 TAS axon guidance
GO:0008380 IEA RNA splicing
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016887 IDA ATPase activity
GO:0019899 IPI enzyme binding
GO:0023026 IDA MHC class II protein complex binding
GO:0030529 IDA ribonucleoprotein complex
GO:0031072 IPI heat shock protein binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0042026 IDA protein refolding
GO:0042623 NAS ATPase activity, coupled
GO:0044822 IDA poly(A) RNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0048026 IEA positive regulation of mRNA splicing, via spliceosome
GO:0051082 IDA unfolded protein binding
GO:0051085 IEA chaperone mediated protein folding requiring cofactor
GO:0051726 IEA regulation of cell cycle
GO:0061024 TAS membrane organization
GO:0061202 TAS clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062 IDA extracellular vesicular exosome
GO:0072318 IEA clathrin coat disassembly
GO:0072562 IDA blood microparticle
GO:1902904 IDA negative regulation of fibril organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037403 HSPA8 (1 of 2) protein_coding Danio_rerio
ENSDARG00000068992 hspa8 protein_coding Danio_rerio
ENSMUSG00000015656 Hspa8 protein_coding Mus_musculus

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