ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: peroxisome proliferator-activated receptor delta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000112033 PPARD 9606 + 6:35342558-35428191 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311565 PPARD-002 35342614-35428178 protein_coding
  ENST00000337400 PPARD-003 35342614-35425393 protein_coding
  ENST00000360694 PPARD-201 35342558-35428191 protein_coding
  ENST00000418635 PPARD-202 35342558-35428191 protein_coding
  ENST00000448077 PPARD-203 35342558-35428191 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000337400ENST00000360694ENST00000418635ENST00000448077
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000337400 N/A 0.328±0.05 N/A N/A 0.726±0.00
ENST00000360694 2.848±0.00 20.982±14.52 1.597±0.00 12.090±0.00 7.731±4.47
ENST00000418635 4.547±0.26 N/A N/A N/A 2.857±1.57
ENST00000448077 4.005±2.08 3.674±1.52 N/A 1.873±0.00 1.606±0.06

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008UQ CIL_0008UQ_0001 VISTA
CIL_0004LU CIL_0004LU_0002 CGP
CIL_0002EQ CIL_0002EQ_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001890 IEA placenta development
GO:0003677 ISS DNA binding
GO:0003700 NAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0003713 IEA transcription coactivator activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005504 IEA fatty acid binding
GO:0005515 IPI protein binding
GO:0005634 NAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006006 NAS glucose metabolic process
GO:0006029 IEA proteoglycan metabolic process
GO:0006091 TAS generation of precursor metabolites and energy
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006629 ISS lipid metabolic process
GO:0006635 ISS fatty acid beta-oxidation
GO:0006776 IEA vitamin A metabolic process
GO:0007507 IEA heart development
GO:0007566 TAS embryo implantation
GO:0008144 IDA drug binding
GO:0008203 TAS cholesterol metabolic process
GO:0008270 IEA zinc ion binding
GO:0008283 ISS cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0008289 IDA lipid binding
GO:0008366 ISS axon ensheathment
GO:0008654 IEA phospholipid biosynthetic process
GO:0009062 TAS fatty acid catabolic process
GO:0009299 IEA mRNA transcription
GO:0009749 IEA response to glucose
GO:0010033 IEA response to organic substance
GO:0010467 TAS gene expression
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 IEA response to activity
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0015758 NAS glucose transport
GO:0015908 ISS fatty acid transport
GO:0019395 IEA fatty acid oxidation
GO:0030154 IEA cell differentiation
GO:0030308 IEA negative regulation of cell growth
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031589 IEA cell-substrate adhesion
GO:0032024 IEA positive regulation of insulin secretion
GO:0032966 IEA negative regulation of collagen biosynthetic process
GO:0033189 IEA response to vitamin A
GO:0042060 IEA wound healing
GO:0042127 IEA regulation of cell proliferation
GO:0043066 IEA negative regulation of apoptotic process
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0043616 IEA keratinocyte proliferation
GO:0045598 IEA regulation of fat cell differentiation
GO:0045600 NAS positive regulation of fat cell differentiation
GO:0045684 IEA positive regulation of epidermis development
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045909 IEA positive regulation of vasodilation
GO:0046697 TAS decidualization
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050728 IEA negative regulation of inflammatory response
GO:0051059 IEA NF-kappaB binding
GO:0051546 IEA keratinocyte migration
GO:0060612 IEA adipose tissue development
GO:0070539 IDA linoleic acid binding
GO:0071456 IEA cellular response to hypoxia
GO:0097190 IMP apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009473 ppardb protein_coding Danio_rerio
ENSDARG00000044525 pparda protein_coding Danio_rerio
ENSMUSG00000002250 Ppard protein_coding Mus_musculus

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