ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SRY (sex determining region Y)-box 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124766 SOX4 9606 + 6:21592769-21598619 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000244745 SOX4-001 21592769-21598619 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000244745
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000244745 6.806±0.90 23.838±4.22 6.780±0.00 22.522±0.00 35.572±26.78

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00084D CIL_00084D_0001 VISTA
CIL_0008YC CIL_0008YC_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000976 ISS transcription regulatory region sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001071 IMP nucleic acid binding transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 ISS RNA polymerase II transcription coactivator activity
GO:0001501 ISS skeletal system development
GO:0001841 ISS neural tube formation
GO:0002328 ISS pro-B cell differentiation
GO:0003183 ISS mitral valve morphogenesis
GO:0003211 ISS cardiac ventricle formation
GO:0003215 ISS cardiac right ventricle morphogenesis
GO:0003289 ISS atrial septum primum morphogenesis
GO:0003357 ISS noradrenergic neuron differentiation
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007507 ISS heart development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0014009 ISS glial cell proliferation
GO:0021510 ISS spinal cord development
GO:0021522 ISS spinal cord motor neuron differentiation
GO:0021782 ISS glial cell development
GO:0030177 ISS positive regulation of Wnt signaling pathway
GO:0030217 ISS T cell differentiation
GO:0031018 IEA endocrine pancreas development
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0031647 IMP regulation of protein stability
GO:0032024 ISS positive regulation of insulin secretion
GO:0035019 IEA somatic stem cell maintenance
GO:0035910 ISS ascending aorta morphogenesis
GO:0042593 ISS glucose homeostasis
GO:0042769 IDA DNA damage response, detection of DNA damage
GO:0043065 IMP positive regulation of apoptotic process
GO:0044798 IEA nuclear transcription factor complex
GO:0045727 IMP positive regulation of translation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046826 IMP negative regulation of protein export from nucleus
GO:0046982 IEA protein heterodimerization activity
GO:0048485 ISS sympathetic nervous system development
GO:0050821 IMP protein stabilization
GO:0060070 ISS canonical Wnt signaling pathway
GO:0060174 ISS limb bud formation
GO:0060412 ISS ventricular septum morphogenesis
GO:0060548 ISS negative regulation of cell death
GO:0060563 ISS neuroepithelial cell differentiation
GO:0060993 ISS kidney morphogenesis
GO:0071333 ISS cellular response to glucose stimulus
GO:0090263 ISS positive regulation of canonical Wnt signaling pathway
GO:2000761 IDA positive regulation of N-terminal peptidyl-lysine acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004588 sox4a protein_coding Danio_rerio
ENSMUSG00000076431 Sox4 protein_coding Mus_musculus

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