ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: complement component 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125730 C3 9606 - 19:6677704-6730562 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000245907 C3-001 6677704-6720682 protein_coding
  ENST00000594005 C3-009 6696614-6697715 retained_intron
  ENST00000594270 C3-017 6712280-6713315 processed_transcript
  ENST00000594936 C3-006 6718034-6720650 retained_intron
  ENST00000595577 C3-005 6712316-6714351 retained_intron
  ENST00000596179 C3-012 6684233-6684632 retained_intron
  ENST00000596238 C3-011 6684560-6686376 retained_intron
  ENST00000596548 C3-018 6680159-6685038 protein_coding
  ENST00000597442 C3-004 6712307-6713788 processed_transcript
  ENST00000598805 C3-010 6686289-6693083 retained_intron
  ENST00000599668 C3-013 6677867-6680151 processed_transcript
  ENST00000599899 C3-002 6677841-6683360 retained_intron
  ENST00000600744 C3-003 6718247-6730562 protein_coding
  ENST00000600763 C3-007 6709756-6710957 retained_intron
  ENST00000601008 C3-015 6677897-6690712 protein_coding
  ENST00000601475 C3-016 6677835-6678330 retained_intron
  ENST00000602053 C3-008 6697662-6702872 retained_intron
  ENST00000602229 C3-014 6677864-6679201 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000245907ENST00000594005ENST00000594270ENST00000594936ENST00000596179ENST00000596238ENST00000596548ENST00000597442ENST00000598805ENST00000599668ENST00000599899ENST00000600744ENST00000600763ENST00000601008ENST00000601475ENST00000602053ENST00000602229
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000245907 N/A 0.874±0.20 9.977±0.00 26.928±0.00 0.142±0.48
ENST00000594005 N/A 0.160±0.00 N/A N/A N/A
ENST00000594270 N/A 0.213±0.00 N/A N/A 0.975±0.00
ENST00000594936 N/A N/A N/A N/A 0.097±0.02
ENST00000596179 N/A 0.630±0.23 N/A N/A 0.310±0.00
ENST00000596238 N/A N/A N/A N/A 0.087±0.00
ENST00000596548 N/A 0.203±0.08 N/A N/A 0.053±0.01
ENST00000597442 N/A N/A N/A N/A 0.228±0.13
ENST00000598805 N/A 0.089±0.00 N/A N/A 0.047±0.00
ENST00000599668 N/A N/A N/A N/A 0.073±0.00
ENST00000599899 N/A 0.057±0.00 N/A N/A N/A
ENST00000600744 N/A 0.222±0.09 N/A N/A 0.269±0.20
ENST00000600763 N/A N/A N/A N/A 0.182±0.00
ENST00000601008 N/A N/A N/A N/A 0.813±0.00
ENST00000601475 N/A 0.742±0.00 198.578±0.00 N/A 2.305±2.01
ENST00000602053 0.834±0.74 0.307±0.07 N/A N/A 0.104±0.06
ENST00000602229 N/A N/A N/A N/A 0.118±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0004C9 CIL_0004C9_0001 CGP
CIL_00010U CIL_00010U_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001798 IEA positive regulation of type IIa hypersensitivity
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001970 IEA positive regulation of activation of membrane attack complex
GO:0004866 IEA endopeptidase inhibitor activity
GO:0005102 TAS receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA:IEA extracellular space
GO:0005886 TAS plasma membrane
GO:0006631 IEA fatty acid metabolic process
GO:0006954 IEA inflammatory response
GO:0006955 TAS immune response
GO:0006956 IMP complement activation
GO:0006957 TAS complement activation, alternative pathway
GO:0006958 IEA complement activation, classical pathway
GO:0007165 TAS signal transduction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0010575 IDA positive regulation vascular endothelial growth factor production
GO:0010828 IDA positive regulation of glucose transport
GO:0010866 IDA regulation of triglyceride biosynthetic process
GO:0010884 IDA positive regulation of lipid storage
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0030449 TAS regulation of complement activation
GO:0031715 IDA C5L2 anaphylatoxin chemotactic receptor binding
GO:0045087 TAS innate immune response
GO:0045745 IDA positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766 IEA positive regulation of angiogenesis
GO:0050766 IEA positive regulation of phagocytosis
GO:0050776 TAS regulation of immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle
GO:2000427 IMP positive regulation of apoptotic cell clearance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001818 c3b.2 protein_coding Danio_rerio
ENSDARG00000012694 c3a.1 protein_coding Danio_rerio
ENSDARG00000052207 c3a.3 protein_coding Danio_rerio
ENSDARG00000087359 c3a.2 protein_coding Danio_rerio
ENSDARG00000093068 c3b.1 protein_coding Danio_rerio
ENSDARG00000093198 C3 (8 of 8) protein_coding Danio_rerio
ENSMUSG00000024164 C3 protein_coding Mus_musculus

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