ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: RAP1B, member of RAS oncogene family
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127314 RAP1B 9606 + 12:68610839-68671901 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000250559 RAP1B-001 68610839-68671901 protein_coding
  ENST00000341355 RAP1B-018 68610908-68657191 protein_coding
  ENST00000378985 RAP1B-008 68610925-68657713 protein_coding
  ENST00000393436 RAP1B-002 68610858-68660522 protein_coding
  ENST00000422358 RAP1B-016 68610908-68650440 protein_coding
  ENST00000425247 RAP1B-013 68610899-68659283 protein_coding
  ENST00000450214 RAP1B-007 68610908-68660124 protein_coding
  ENST00000453560 RAP1B-023 68610925-68656364 protein_coding
  ENST00000460800 RAP1B-003 68610855-68650882 processed_transcript
  ENST00000463493 RAP1B-005 68610908-68659497 processed_transcript
  ENST00000485252 RAP1B-027 68610933-68652014 protein_coding
  ENST00000489473 RAP1B-017 68610908-68648757 protein_coding
  ENST00000501412 RAP1B-012 68610899-68650041 retained_intron
  ENST00000534899 RAP1B-024 68610925-68654190 protein_coding
  ENST00000535492 RAP1B-026 68610929-68657139 protein_coding
  ENST00000537460 RAP1B-006 68610908-68659401 protein_coding
  ENST00000538283 RAP1B-015 68610908-68654232 protein_coding
  ENST00000538877 RAP1B-029 68610938-68652028 protein_coding
  ENST00000538980 RAP1B-020 68610918-68657150 protein_coding
  ENST00000539091 RAP1B-010 68610929-68659647 protein_coding
  ENST00000540209 RAP1B-009 68610925-68659870 protein_coding
  ENST00000540781 RAP1B-025 68610929-68656398 protein_coding
  ENST00000541167 RAP1B-014 68610908-68654207 protein_coding
  ENST00000541216 RAP1B-004 68611025-68656637 protein_coding
  ENST00000541386 RAP1B-028 68610938-68648757 protein_coding
  ENST00000541968 RAP1B-033 68651682-68654219 retained_intron
  ENST00000542018 RAP1B-022 68610919-68654222 protein_coding
  ENST00000542145 RAP1B-011 68610929-68659754 protein_coding
  ENST00000543393 RAP1B-021 68610919-68659626 protein_coding
  ENST00000543697 RAP1B-030 68610939-68659441 protein_coding
  ENST00000544639 RAP1B-032 68650244-68656413 retained_intron
  ENST00000545270 RAP1B-019 68610913-68656348 protein_coding
  ENST00000545720 RAP1B-031 68610961-68654182 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000250559ENST00000341355ENST00000393436ENST00000453560ENST00000460800ENST00000542145ENST00000543393ENST00000543697
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000250559 N/A N/A N/A N/A 0.706±0.02
ENST00000341355 N/A N/A N/A N/A 38.126±9.79
ENST00000393436 33.075±5.03 59.330±14.68 43.044±0.00 93.265±0.00 62.682±56.35
ENST00000453560 N/A N/A N/A N/A 22.399±0.00
ENST00000460800 N/A N/A N/A N/A 17.228±0.00
ENST00000542145 N/A N/A N/A 30.996±0.00 13.115±2.01
ENST00000543393 N/A N/A N/A N/A 1.700±0.00
ENST00000543697 N/A N/A N/A N/A 16.958±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003924 IDA:IEA GTPase activity
GO:0005515 IPI protein binding
GO:0005525 IEA:IDA GTP binding
GO:0005622 IDA:IEA intracellular
GO:0005811 IDA lipid particle
GO:0005829 IDA cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006112 TAS energy reserve metabolic process
GO:0006184 IEA GTP catabolic process
GO:0006886 IEA intracellular protein transport
GO:0006913 IEA nucleocytoplasmic transport
GO:0007165 IEA signal transduction
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0008283 IEA cell proliferation
GO:0015031 IEA protein transport
GO:0016020 IEA:TAS membrane
GO:0019003 IDA GDP binding
GO:0030168 TAS platelet activation
GO:0032403 IDA protein complex binding
GO:0032486 IMP Rap protein signal transduction
GO:0044281 TAS small molecule metabolic process
GO:0045955 IEA negative regulation of calcium ion-dependent exocytosis
GO:0050796 TAS regulation of insulin secretion
GO:0061028 IMP establishment of endothelial barrier
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071320 IDA cellular response to cAMP
GO:1901888 IMP regulation of cell junction assembly
GO:2000114 IMP regulation of establishment of cell polarity
GO:2000301 IEA negative regulation of synaptic vesicle exocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008867 rap1b protein_coding Danio_rerio
ENSMUSG00000052681 Rap1b protein_coding Mus_musculus

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