ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: glutamate decarboxylase 1 (brain, 67kDa)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128683 GAD1 9606 + 2:170813213-170861151 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344257 GAD1-002 170816912-170842759 protein_coding
  ENST00000358196 GAD1-001 170816562-170861151 protein_coding
  ENST00000375272 GAD1-201 170816690-170842756 protein_coding
  ENST00000414527 GAD1-013 170817038-170859916 nonsense_mediated_decay
  ENST00000429023 GAD1-004 170818611-170844157 processed_transcript
  ENST00000445006 GAD1-008 170816114-170822116 protein_coding
  ENST00000454603 GAD1-007 170813213-170829585 protein_coding
  ENST00000455008 GAD1-009 170817255-170830991 protein_coding
  ENST00000456864 GAD1-010 170817769-170831008 protein_coding
  ENST00000462739 GAD1-014 170843802-170845543 retained_intron
  ENST00000478562 GAD1-006 170852488-170861147 retained_intron
  ENST00000485013 GAD1-011 170821718-170829620 retained_intron
  ENST00000486850 GAD1-015 170822087-170829872 protein_coding
  ENST00000488724 GAD1-005 170849067-170860253 retained_intron
  ENST00000493270 GAD1-012 170828968-170831090 retained_intron
  ENST00000493875 GAD1-003 170817770-170861151 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHUVECENST00000344257ENST00000358196ENST00000414527ENST00000429023ENST00000445006ENST00000454603ENST00000455008ENST00000456864ENST00000478562ENST00000485013ENST00000486850ENST00000488724ENST00000493270ENST00000493875
Transcript ID HAoEC HHSEC HUVEC
ENST00000344257 0.386±0.22 N/A 0.209±0.16
ENST00000358196 0.090±0.02 N/A 0.040±0.02
ENST00000414527 N/A N/A 0.088±0.06
ENST00000429023 0.361±0.23 N/A 0.093±0.05
ENST00000445006 0.063±0.01 N/A N/A
ENST00000454603 N/A N/A 0.069±0.03
ENST00000455008 0.054±0.00 N/A 0.178±0.00
ENST00000456864 0.018±0.00 N/A N/A
ENST00000478562 0.012±0.00 0.014±0.00 0.007±0.00
ENST00000485013 N/A N/A 0.083±0.00
ENST00000486850 0.175±0.06 N/A 0.188±0.06
ENST00000488724 0.150±0.00 N/A 0.083±0.06
ENST00000493270 N/A N/A 0.041±0.04
ENST00000493875 0.086±0.03 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003SB CIL_0003SB_0002 CGP
CIL_0003SC CIL_0003SC_0002 CGP

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004351 IDA glutamate decarboxylase activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005886 TAS plasma membrane
GO:0006520 IEA cellular amino acid metabolic process
GO:0006538 TAS glutamate catabolic process
GO:0006540 TAS glutamate decarboxylation to succinate
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0008152 IEA metabolic process
GO:0009449 IEA gamma-aminobutyric acid biosynthetic process
GO:0012506 NAS vesicle membrane
GO:0016595 IEA glutamate binding
GO:0016829 IEA lyase activity
GO:0016831 IEA carboxy-lyase activity
GO:0018352 TAS protein-pyridoxal-5-phosphate linkage
GO:0019752 IEA carboxylic acid metabolic process
GO:0030170 IEA pyridoxal phosphate binding
GO:0042136 IEA neurotransmitter biosynthetic process
GO:0042493 IEA response to drug
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IEA protein N-terminus binding
GO:0061202 TAS clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027419 gad1b protein_coding Danio_rerio
ENSDARG00000093411 gad1a protein_coding Danio_rerio
ENSMUSG00000070880 Gad1 protein_coding Mus_musculus
ENSMUSG00000090665 Gad1-ps protein_coding Mus_musculus

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