ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: DNA (cytosine-5-)-methyltransferase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000130816 DNMT1 9606 - 19:10133345-10231286 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340748 DNMT1-001 10133346-10195135 protein_coding
  ENST00000359526 DNMT1-002 10133540-10195079 protein_coding
  ENST00000540357 DNMT1-201 10133347-10195135 protein_coding
  ENST00000585843 DNMT1-018 10154664-10160263 retained_intron
  ENST00000585920 DNMT1-017 10160207-10162983 retained_intron
  ENST00000586086 DNMT1-014 10180463-10184559 processed_transcript
  ENST00000586588 DNMT1-004 10133345-10144754 retained_intron
  ENST00000586667 DNMT1-020 10148925-10151697 retained_intron
  ENST00000586799 DNMT1-019 10149948-10154977 nonsense_mediated_decay
  ENST00000586800 DNMT1-010 10180355-10201197 protein_coding
  ENST00000586988 DNMT1-015 10168330-10194904 nonsense_mediated_decay
  ENST00000587197 DNMT1-026 10137888-10140195 retained_intron
  ENST00000587604 DNMT1-023 10140529-10142074 retained_intron
  ENST00000588118 DNMT1-009 10175540-10201192 protein_coding
  ENST00000588913 DNMT1-008 10133367-10140130 nonsense_mediated_decay
  ENST00000588952 DNMT1-012 10173090-10231286 protein_coding
  ENST00000589091 DNMT1-025 10140689-10141446 retained_intron
  ENST00000589294 DNMT1-027 10137467-10138470 retained_intron
  ENST00000589349 DNMT1-016 10159912-10166671 retained_intron
  ENST00000589351 DNMT1-024 10140254-10141572 retained_intron
  ENST00000589538 DNMT1-029 10140030-10143901 processed_transcript
  ENST00000590619 DNMT1-005 10177319-10180381 protein_coding
  ENST00000591239 DNMT1-022 10141697-10143791 retained_intron
  ENST00000591764 DNMT1-007 10159944-10166666 retained_intron
  ENST00000591798 DNMT1-028 10133351-10135517 processed_transcript
  ENST00000592054 DNMT1-013 10175563-10194626 protein_coding
  ENST00000592342 DNMT1-011 10175542-10231273 protein_coding
  ENST00000592705 DNMT1-006 10133346-10194934 nonsense_mediated_decay
  ENST00000593049 DNMT1-021 10140280-10142896 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000340748ENST00000359526ENST00000540357ENST00000586588ENST00000588913ENST00000591798ENST00000592705
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000340748 N/A 8.738±0.97 N/A 5.764±0.00 5.072±3.97
ENST00000359526 N/A 4.750±2.02 N/A N/A 2.931±2.29
ENST00000540357 1.859±0.27 5.705±1.19 2.567±0.00 N/A 4.537±1.86
ENST00000586588 N/A N/A N/A N/A 0.643±0.00
ENST00000588913 7.413±1.52 N/A N/A N/A N/A
ENST00000591798 36.600±0.00 N/A 36.071±0.00 N/A 29.124±0.00
ENST00000592705 N/A 7.058±2.69 N/A 5.990±0.00 4.170±4.38

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0004BQ CIL_0004BQ_0002 CGP
CIL_000773 CIL_000773_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000792 IEA heterochromatin
GO:0003677 IDA:IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003723 IEA RNA binding
GO:0003886 IDA:IEA DNA (cytosine-5-)-methyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005657 IEA replication fork
GO:0005721 IEA pericentric heterochromatin
GO:0006306 TAS DNA methylation
GO:0006351 IEA transcription, DNA-templated
GO:0008134 IEA transcription factor binding
GO:0008168 IEA methyltransferase activity
GO:0008270 IEA zinc ion binding
GO:0008327 IEA methyl-CpG binding
GO:0009008 IDA DNA-methyltransferase activity
GO:0010216 IDA maintenance of DNA methylation
GO:0010468 IEA regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0016458 IEA gene silencing
GO:0016568 IEA chromatin modification
GO:0042127 IEA regulation of cell proliferation
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0051571 IMP positive regulation of histone H3-K4 methylation
GO:0051573 IMP negative regulation of histone H3-K9 methylation
GO:0071230 IEA cellular response to amino acid stimulus
GO:0090116 IEA C-5 methylation of cytosine

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030756 dnmt1 protein_coding Danio_rerio
ENSMUSG00000004099 Dnmt1 protein_coding Mus_musculus

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