ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: lysyl oxidase-like 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134013 LOXL2 9606 - 8:23297189-23425328 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000389131 LOXL2-001 23297189-23404240 protein_coding
  ENST00000518083 LOXL2-013 23360166-23371126 protein_coding
  ENST00000518472 LOXL2-003 23331437-23333553 processed_transcript
  ENST00000518878 LOXL2-011 23319885-23341176 nonsense_mediated_decay
  ENST00000519243 LOXL2-010 23368065-23404226 protein_coding
  ENST00000519809 LOXL2-004 23319961-23329115 processed_transcript
  ENST00000520349 LOXL2-005 23319885-23333495 protein_coding
  ENST00000520617 LOXL2-008 23316734-23320005 retained_intron
  ENST00000520871 LOXL2-009 23360090-23425328 protein_coding
  ENST00000520925 LOXL2-006 23321737-23333636 retained_intron
  ENST00000522446 LOXL2-007 23319927-23328768 retained_intron
  ENST00000523833 LOXL2-016 23316984-23404126 protein_coding
  ENST00000524075 LOXL2-015 23403906-23425301 retained_intron
  ENST00000524144 LOXL2-014 23360090-23425291 protein_coding
  ENST00000524168 LOXL2-012 23360204-23404076 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000389131
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000389131 29.372±17.86 151.788±94.49 135.902±0.00 111.758±80.47

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008FQ CIL_0008FQ_0001 VISTA
CIL_0007YD CIL_0007YD_0001 VISTA
CIL_00016U CIL_00016U_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 ISS response to hypoxia
GO:0001837 IDA epithelial to mesenchymal transition
GO:0001935 IMP endothelial cell proliferation
GO:0002040 IMP sprouting angiogenesis
GO:0003682 IDA chromatin binding
GO:0003714 IDA transcription corepressor activity
GO:0004720 IDA protein-lysine 6-oxidase activity
GO:0005044 IEA scavenger receptor activity
GO:0005507 IEA copper ion binding
GO:0005515 IPI protein binding
GO:0005604 ISS basement membrane
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005694 IEA chromosome
GO:0006351 IEA transcription, DNA-templated
GO:0006464 IDA cellular protein modification process
GO:0006898 IEA receptor-mediated endocytosis
GO:0007155 TAS cell adhesion
GO:0007568 TAS aging
GO:0009055 TAS electron carrier activity
GO:0016020 IEA membrane
GO:0016570 IDA histone modification
GO:0016641 IEA oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0018277 IDA protein deamination
GO:0030199 IMP collagen fibril organization
GO:0032332 ISS positive regulation of chondrocyte differentiation
GO:0035064 IDA methylated histone binding
GO:0043542 IMP endothelial cell migration
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0046688 IDA response to copper ion
GO:0055114 IDA:IEA oxidation-reduction process
GO:0070492 IDA oligosaccharide binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044010 loxl2a protein_coding Danio_rerio
ENSDARG00000044074 loxl2b protein_coding Danio_rerio
ENSMUSG00000034205 Loxl2 protein_coding Mus_musculus

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