ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: IQ motif containing GTPase activating protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140575 IQGAP1 9606 + 15:90388218-90502243 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268182 IQGAP1-001 90388218-90502243 protein_coding
  ENST00000558003 IQGAP1-009 90473548-90474239 retained_intron
  ENST00000558491 IQGAP1-013 90484245-90486558 retained_intron
  ENST00000558957 IQGAP1-002 90494027-90501389 retained_intron
  ENST00000559031 IQGAP1-015 90486883-90491620 retained_intron
  ENST00000559674 IQGAP1-017 90487469-90494768 retained_intron
  ENST00000559682 IQGAP1-007 90426152-90429849 retained_intron
  ENST00000559809 IQGAP1-005 90388355-90391932 protein_coding
  ENST00000560020 IQGAP1-010 90474484-90475754 processed_transcript
  ENST00000560218 IQGAP1-012 90483205-90486051 retained_intron
  ENST00000560373 IQGAP1-008 90467482-90473078 protein_coding
  ENST00000560418 IQGAP1-006 90388277-90440528 protein_coding
  ENST00000560733 IQGAP1-011 90474322-90477103 retained_intron
  ENST00000560738 IQGAP1-004 90388261-90500371 protein_coding
  ENST00000561086 IQGAP1-003 90496714-90502238 retained_intron
  ENST00000561132 IQGAP1-016 90486095-90491671 retained_intron
  ENST00000561461 IQGAP1-014 90486743-90492616 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000268182ENST00000560738ENST00000561086
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000268182 1.755±0.00 49.421±5.60 N/A 75.120±0.00 52.081±33.05
ENST00000560738 N/A N/A N/A N/A 10.678±10.12
ENST00000561086 27.152±1.70 N/A 15.003±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008FE CIL_0008FE_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001817 IEA regulation of cytokine production
GO:0005095 TAS GTPase inhibitor activity
GO:0005096 TAS GTPase activator activity
GO:0005099 IEA Ras GTPase activator activity
GO:0005509 TAS calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005516 IPI calmodulin binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005874 IDA microtubule
GO:0005884 TAS actin filament
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0006112 TAS energy reserve metabolic process
GO:0007165 TAS:IEA signal transduction
GO:0007173 IMP epidermal growth factor receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008543 IEA fibroblast growth factor receptor signaling pathway
GO:0015629 ISS actin cytoskeleton
GO:0015630 ISS microtubule cytoskeleton
GO:0016020 IEA membrane
GO:0016328 IEA lateral plasma membrane
GO:0017048 IEA Rho GTPase binding
GO:0019901 IPI protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0030054 IDA cell junction
GO:0030424 ISS axon
GO:0030426 ISS growth cone
GO:0030496 IDA midbody
GO:0030529 IEA ribonucleoprotein complex
GO:0031234 IDA extrinsic component of cytoplasmic side of plasma membrane
GO:0031252 IEA cell leading edge
GO:0032318 IEA regulation of Ras GTPase activity
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032403 IEA protein complex binding
GO:0035305 IEA negative regulation of dephosphorylation
GO:0036057 ISS slit diaphragm
GO:0036120 IEA cellular response to platelet-derived growth factor stimulus
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0043005 ISS neuron projection
GO:0043086 TAS negative regulation of catalytic activity
GO:0043234 IEA protein complex
GO:0043539 IDA protein serine/threonine kinase activator activity
GO:0043547 TAS positive regulation of GTPase activity
GO:0044281 TAS small molecule metabolic process
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0045860 IMP positive regulation of protein kinase activity
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048365 IEA Rac GTPase binding
GO:0050796 TAS regulation of insulin secretion
GO:0070062 IDA extracellular vesicular exosome
GO:0071277 IDA cellular response to calcium ion
GO:0071364 IMP cellular response to epidermal growth factor stimulus
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:0072015 ISS glomerular visceral epithelial cell development
GO:1990138 IMP neuron projection extension

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078888 iqgap1 protein_coding Danio_rerio
ENSMUSG00000030536 Iqgap1 protein_coding Mus_musculus

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