ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141655 TNFRSF11A 9606 + 18:62325287-62391292 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000269485 TNFRSF11A-002 62325287-62387659 protein_coding
  ENST00000586569 TNFRSF11A-001 62325315-62391292 protein_coding
  ENST00000587697 TNFRSF11A-004 62357903-62360043 retained_intron
  ENST00000592013 TNFRSF11A-003 62325326-62336786 retained_intron
  ENST00000616710 TNFRSF11A-201 62325287-62387710 protein_coding
  ENST00000617039 TNFRSF11A-202 62325287-62387710 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000269485ENST00000586569ENST00000616710ENST00000617039
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000269485 0.702±0.10 0.717±0.03 0.803±0.00 N/A 0.724±0.35
ENST00000586569 0.137±0.00 0.586±0.28 N/A 0.839±0.00 0.698±0.55
ENST00000616710 0.431±0.00 1.468±0.80 N/A N/A 1.504±0.92
ENST00000617039 0.201±0.00 0.883±0.46 N/A 2.618±0.00 1.006±0.47

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00071U CIL_00071U_0001 CGP
CIL_00076G CIL_00076G_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0002250 IMP adaptive immune response
GO:0002548 NAS monocyte chemotaxis
GO:0004872 TAS receptor activity
GO:0004888 IDA transmembrane signaling receptor activity
GO:0005031 ISS tumor necrosis factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007275 IEA multicellular organismal development
GO:0008284 TAS positive regulation of cell proliferation
GO:0009314 IEA response to radiation
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0016021 IEA integral component of membrane
GO:0019955 IPI cytokine binding
GO:0030316 IMP osteoclast differentiation
GO:0032496 ISS response to lipopolysaccharide
GO:0033209 ISS tumor necrosis factor-mediated signaling pathway
GO:0034097 IMP response to cytokine
GO:0034612 ISS response to tumor necrosis factor
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0046872 IEA metal ion binding
GO:0048535 IEA lymph node development
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0060086 ISS circadian temperature homeostasis
GO:0060749 IEA mammary gland alveolus development
GO:0070555 ISS response to interleukin-1
GO:0071812 ISS positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IMP TNFSF11-mediated signaling pathway
GO:0071848 IMP positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087804 tnfrsf11a protein_coding Danio_rerio
ENSMUSG00000026321 Tnfrsf11a protein_coding Mus_musculus

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