ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143207 RFWD2 9606 - 1:175944831-176207493 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308769 RFWD2-010 175945153-176206978 protein_coding
  ENST00000367666 RFWD2-003 175944832-176184664 protein_coding
  ENST00000367667 RFWD2-002 175944831-176206691 nonsense_mediated_decay
  ENST00000367669 RFWD2-001 175944831-176207493 protein_coding
  ENST00000459744 RFWD2-008 176043216-176135082 protein_coding
  ENST00000461830 RFWD2-004 175944831-176081256 retained_intron
  ENST00000474194 RFWD2-006 176135010-176207083 nonsense_mediated_decay
  ENST00000482305 RFWD2-005 175944853-175947326 retained_intron
  ENST00000491600 RFWD2-007 176116646-176206440 nonsense_mediated_decay
  ENST00000498306 RFWD2-009 176085866-176206381 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000308769ENST00000367666ENST00000367667ENST00000367669ENST00000459744ENST00000461830ENST00000482305
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000308769 N/A 2.665±0.89 N/A 3.377±0.00 2.590±0.99
ENST00000367666 6.374±0.00 5.195±1.60 4.390±0.00 6.319±0.00 4.777±2.78
ENST00000367667 4.832±1.76 5.735±2.63 N/A 3.183±0.00 3.886±1.26
ENST00000367669 N/A 1.975±0.80 N/A 3.856±0.00 4.530±2.01
ENST00000459744 N/A N/A N/A N/A 10.690±2.67
ENST00000461830 N/A N/A 2.461±0.00 N/A 2.563±0.00
ENST00000482305 25.615±3.85 N/A 58.298±0.00 N/A N/A

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 IEA Golgi membrane
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008270 IEA zinc ion binding
GO:0010212 IDA response to ionizing radiation
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046872 IEA metal ion binding
GO:0061630 IMP ubiquitin protein ligase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079329 rfwd2 protein_coding Danio_rerio
ENSMUSG00000040782 Rfwd2 protein_coding Mus_musculus

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