ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: general transcription factor IIH, polypeptide 2, 44kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145736 GTF2H2 9606 - 5:71034957-71067689 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274400 GTF2H2-001 71034957-71067601 protein_coding
  ENST00000330280 GTF2H2-003 71035076-71067650 protein_coding
  ENST00000508592 GTF2H2-020 71061410-71062763 retained_intron
  ENST00000517900 GTF2H2-016 71035582-71067652 protein_coding
  ENST00000518275 GTF2H2-021 71062752-71067638 processed_transcript
  ENST00000518898 GTF2H2-004 71035329-71061765 nonsense_mediated_decay
  ENST00000519783 GTF2H2-002 71035016-71067601 nonsense_mediated_decay
  ENST00000521602 GTF2H2-022 71061751-71067648 protein_coding
  ENST00000521858 GTF2H2-011 71057875-71062799 retained_intron
  ENST00000521942 GTF2H2-008 71047456-71062799 retained_intron
  ENST00000522654 GTF2H2-009 71048089-71067674 retained_intron
  ENST00000523003 GTF2H2-010 71055030-71067689 retained_intron
  ENST00000523693 GTF2H2-024 71060507-71067676 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000274400ENST00000330280ENST00000518898ENST00000519783ENST00000521858ENST00000521942ENST00000522654ENST00000523003ENST00000523693
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000274400 N/A 0.223±0.18 N/A N/A 0.276±0.19
ENST00000330280 N/A N/A N/A N/A 0.105±0.00
ENST00000518898 0.290±0.23 0.290±0.08 N/A 0.512±0.00 0.195±0.00
ENST00000519783 N/A 0.882±0.00 N/A N/A 0.199±0.13
ENST00000521858 N/A N/A N/A N/A 0.217±0.00
ENST00000521942 0.378±0.00 0.902±0.89 0.340±0.00 1.886±0.00 0.642±0.39
ENST00000522654 N/A 1.402±0.00 N/A N/A 0.266±0.15
ENST00000523003 N/A 0.379±0.24 0.274±0.00 N/A 0.397±0.26
ENST00000523693 N/A 1.757±0.00 N/A N/A 0.428±0.25

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0004ZF CIL_0004ZF_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000439 IEA core TFIIH complex
GO:0000718 TAS nucleotide-excision repair, DNA damage removal
GO:0002031 IMP G-protein coupled receptor internalization
GO:0003676 TAS nucleic acid binding
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0004672 IDA protein kinase activity
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0005675 IDA holo TFIIH complex
GO:0006200 IDA ATP catabolic process
GO:0006281 TAS:IEA DNA repair
GO:0006283 TAS transcription-coupled nucleotide-excision repair
GO:0006289 TAS:IEA nucleotide-excision repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006360 TAS transcription from RNA polymerase I promoter
GO:0006361 TAS transcription initiation from RNA polymerase I promoter
GO:0006362 TAS transcription elongation from RNA polymerase I promoter
GO:0006363 TAS termination of RNA polymerase I transcription
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006368 TAS transcription elongation from RNA polymerase II promoter
GO:0006370 TAS 7-methylguanosine mRNA capping
GO:0006412 TAS translation
GO:0006468 IDA protein phosphorylation
GO:0008094 IDA DNA-dependent ATPase activity
GO:0008135 TAS translation factor activity, nucleic acid binding
GO:0008270 IEA zinc ion binding
GO:0008353 IDA RNA polymerase II carboxy-terminal domain kinase activity
GO:0009411 TAS response to UV
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0047485 IPI protein N-terminus binding
GO:0050434 TAS positive regulation of viral transcription

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016514 gtf2h2 protein_coding Danio_rerio
ENSMUSG00000021639 Gtf2h2 protein_coding Mus_musculus

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