ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: B-Raf proto-oncogene, serine/threonine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157764 BRAF 9606 - 7:140719327-140924764 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000288602 BRAF-001 140734479-140924764 protein_coding
  ENST00000469930 BRAF-004 140834061-140924709 retained_intron
  ENST00000479537 BRAF-005 140734521-140754211 nonsense_mediated_decay
  ENST00000496384 BRAF-003 140719327-140783157 protein_coding
  ENST00000497784 BRAF-002 140734597-140924658 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHMVEC-DHUVECENST00000288602ENST00000469930ENST00000496384ENST00000497784
Transcript ID HAoEC HHSEC HMVEC-D HUVEC
ENST00000288602 4.345±0.33 N/A N/A 2.371±0.07
ENST00000469930 N/A N/A N/A 5.907±0.30
ENST00000496384 2.447±0.93 2.261±0.00 3.005±0.00 2.578±0.80
ENST00000497784 N/A N/A N/A 7.458±0.77

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00039Z CIL_00039Z_0001 CGP
CIL_00039Y CIL_00039Y_0001 CGP
CIL_000605 CIL_000605_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0002318 IEA myeloid progenitor cell differentiation
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005057 IEA receptor signaling protein activity
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007268 TAS synaptic transmission
GO:0008542 IEA visual learning
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009887 TAS organ morphogenesis
GO:0010628 IMP positive regulation of gene expression
GO:0010764 IEA negative regulation of fibroblast migration
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030154 IEA cell differentiation
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0035019 IEA somatic stem cell maintenance
GO:0035556 IEA intracellular signal transduction
GO:0035690 IEA cellular response to drug
GO:0042127 IEA regulation of cell proliferation
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043066 IDA negative regulation of apoptotic process
GO:0043367 IEA CD4-positive, alpha-beta T cell differentiation
GO:0043368 IEA positive T cell selection
GO:0043434 IEA response to peptide hormone
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044297 IEA cell body
GO:0046632 IEA alpha-beta T cell differentiation
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051291 IEA protein heterooligomerization
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051591 IEA response to cAMP
GO:0060291 IEA long-term synaptic potentiation
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071277 IDA cellular response to calcium ion
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading
GO:2000301 IEA negative regulation of synaptic vesicle exocytosis
GO:2000352 IEA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017661 braf protein_coding Danio_rerio
ENSMUSG00000002413 Braf protein_coding Mus_musculus

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