ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000158571 PFKFB1 9606 - X:54932961-54998534 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374992 PFKFB1-201 54933134-54994078 protein_coding
  ENST00000375006 PFKFB1-001 54932961-54994078 protein_coding
  ENST00000545676 PFKFB1-202 54933134-54998534 protein_coding
  ENST00000614686 PFKFB1-203 54933387-54994022 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000374992ENST00000375006ENST00000545676ENST00000614686
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000374992 0.432±0.00 0.084±0.05 0.200±0.00 0.248±0.00 0.029±0.02
ENST00000375006 N/A 0.028±0.00 N/A N/A 0.059±0.00
ENST00000545676 N/A 0.109±0.05 0.453±0.00 N/A 0.087±0.07
ENST00000614686 N/A 0.101±0.06 N/A N/A 0.073±0.02

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003873 IEA 6-phosphofructo-2-kinase activity
GO:0004331 IEA fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005975 TAS carbohydrate metabolic process
GO:0006000 IEA fructose metabolic process
GO:0006003 IEA fructose 2,6-bisphosphate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006094 TAS gluconeogenesis
GO:0006096 TAS glycolytic process
GO:0006112 TAS energy reserve metabolic process
GO:0016301 IEA kinase activity
GO:0016311 IEA dephosphorylation
GO:0019900 IEA kinase binding
GO:0031100 IEA organ regeneration
GO:0032868 IEA response to insulin
GO:0033133 IEA positive regulation of glucokinase activity
GO:0033762 IEA response to glucagon
GO:0035556 TAS intracellular signal transduction
GO:0042594 IEA response to starvation
GO:0042802 IEA identical protein binding
GO:0043540 IDA 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
GO:0044281 TAS small molecule metabolic process
GO:0046835 IEA carbohydrate phosphorylation
GO:0051384 IEA response to glucocorticoid
GO:0051591 IEA response to cAMP
GO:0070095 IEA fructose-6-phosphate binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037140 pfkfb1 protein_coding Danio_rerio
ENSDARG00000074457 PFKFB1 (2 of 2) protein_coding Danio_rerio
ENSMUSG00000025271 Pfkfb1 protein_coding Mus_musculus

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