ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: angiotensin I converting enzyme
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159640 ACE 9606 + 17:63477061-63498380 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290863 ACE-007 63484840-63497618 protein_coding
  ENST00000290866 ACE-001 63477071-63497620 protein_coding
  ENST00000413513 ACE-009 63484846-63497505 protein_coding
  ENST00000428043 ACE-201 63477061-63498380 protein_coding
  ENST00000577418 ACE-018 63489883-63497163 processed_transcript
  ENST00000578679 ACE-019 63493756-63494467 retained_intron
  ENST00000578839 ACE-008 63484846-63497438 nonsense_mediated_decay
  ENST00000579204 ACE-015 63484868-63489040 nonsense_mediated_decay
  ENST00000579314 ACE-006 63484846-63497618 nonsense_mediated_decay
  ENST00000579409 ACE-020 63494404-63497153 protein_coding
  ENST00000579462 ACE-005 63477070-63478517 retained_intron
  ENST00000579726 ACE-013 63484338-63487073 nonsense_mediated_decay
  ENST00000580318 ACE-012 63477493-63480425 nonsense_mediated_decay
  ENST00000582005 ACE-014 63484844-63489091 nonsense_mediated_decay
  ENST00000582244 ACE-021 63496140-63496985 retained_intron
  ENST00000582627 ACE-011 63477482-63481185 protein_coding
  ENST00000582678 ACE-003 63477061-63485772 nonsense_mediated_decay
  ENST00000582761 ACE-017 63487001-63494405 protein_coding
  ENST00000583336 ACE-010 63477061-63478898 processed_transcript
  ENST00000583645 ACE-022 63490348-63493446 retained_intron
  ENST00000584529 ACE-004 63477061-63483558 processed_transcript
  ENST00000584865 ACE-016 63486823-63493657 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000290863ENST00000290866ENST00000428043ENST00000579204ENST00000579462ENST00000584529
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000290863 N/A N/A N/A 6.392±0.00
ENST00000290866 4.541±0.00 2.544±0.85 3.552±0.00 13.597±11.54
ENST00000428043 N/A 2.025±0.00 1.639±0.00 15.798±19.18
ENST00000579204 N/A 3.088±0.00 N/A N/A
ENST00000579462 N/A N/A N/A 0.038±0.00
ENST00000584529 N/A 2.237±0.00 N/A 1.789±0.07

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0009B9 CIL_0009B9_0001 VISTA
CIL_0006ZU CIL_0006ZU_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IMP kidney development
GO:0001974 IC blood vessel remodeling
GO:0002003 TAS angiotensin maturation
GO:0002005 IC angiotensin catabolic process in blood
GO:0002019 IC regulation of renal output by angiotensin
GO:0003081 IC regulation of systemic arterial blood pressure by renin-angiotensin
GO:0003779 IDA actin binding
GO:0004175 IDA endopeptidase activity
GO:0004180 IEA carboxypeptidase activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005768 IDA endosome
GO:0005886 IDA plasma membrane
GO:0006508 IEA proteolysis
GO:0008144 IDA drug binding
GO:0008217 ISS regulation of blood pressure
GO:0008237 ISS:IEA metallopeptidase activity
GO:0008241 ISS:IEA peptidyl-dipeptidase activity
GO:0008270 IDA zinc ion binding
GO:0009897 IDA external side of plasma membrane
GO:0014910 ISS regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019229 IC regulation of vasoconstriction
GO:0031404 IDA chloride ion binding
GO:0031711 IPI bradykinin receptor binding
GO:0032943 IC mononuclear cell proliferation
GO:0042312 IC regulation of vasodilation
GO:0042447 ISS hormone catabolic process
GO:0043171 IDA peptide catabolic process
GO:0044267 TAS cellular protein metabolic process
GO:0046872 IEA metal ion binding
GO:0050482 IDA arachidonic acid secretion
GO:0060218 IC hematopoietic stem cell differentiation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079166 ace protein_coding Danio_rerio
ENSMUSG00000020681 Ace protein_coding Mus_musculus

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