ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: sequestosome 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000161011 SQSTM1 9606 + 5:179806398-179838078 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360718 SQSTM1-002 179822485-179837255 protein_coding
  ENST00000389805 SQSTM1-001 179820759-179838078 protein_coding
  ENST00000422245 SQSTM1-003 179818878-179824323 protein_coding
  ENST00000453046 SQSTM1-008 179820905-179823939 nonsense_mediated_decay
  ENST00000464493 SQSTM1-005 179820607-179824287 processed_transcript
  ENST00000466342 SQSTM1-007 179823858-179833386 retained_intron
  ENST00000481335 SQSTM1-004 179818967-179823968 processed_transcript
  ENST00000485412 SQSTM1-006 179823565-179824314 retained_intron
  ENST00000504627 SQSTM1-017 179820905-179824057 protein_coding
  ENST00000506042 SQSTM1-014 179806398-179813024 processed_transcript
  ENST00000506690 SQSTM1-010 179807324-179813598 processed_transcript
  ENST00000508284 SQSTM1-016 179820878-179824237 nonsense_mediated_decay
  ENST00000510187 SQSTM1-013 179820921-179837218 protein_coding
  ENST00000512234 SQSTM1-011 179811615-179813641 processed_transcript
  ENST00000514093 SQSTM1-015 179806408-179825226 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000360718ENST00000389805ENST00000466342
Transcript ID HAoEC HUVEC
ENST00000360718 108.656±0.00 N/A
ENST00000389805 68.595±4.32 96.003±41.31
ENST00000466342 390.796±112.76 528.492±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0000XE CIL_0000XE_0002 CGP
CIL_0000XF CIL_0000XF_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000407 IEA pre-autophagosomal structure
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002376 IEA immune system process
GO:0004674 NAS protein serine/threonine kinase activity
GO:0005080 IPI protein kinase C binding
GO:0005515 IPI:IEA protein binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005764 IEA lysosome
GO:0005768 IEA endosome
GO:0005776 IDA autophagic vacuole
GO:0005783 IEA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006468 NAS protein phosphorylation
GO:0006511 TAS ubiquitin-dependent protein catabolic process
GO:0006914 IMP autophagy
GO:0006950 TAS response to stress
GO:0008104 TAS protein localization
GO:0008270 IEA zinc ion binding
GO:0016197 TAS endosomal transport
GO:0016234 IDA inclusion body
GO:0016235 IEA aggresome
GO:0016236 ISS macroautophagy
GO:0016239 IMP positive regulation of macroautophagy
GO:0016605 IDA PML body
GO:0019901 IDA protein kinase binding
GO:0030154 IEA cell differentiation
GO:0030971 TAS receptor tyrosine kinase binding
GO:0031410 IEA cytoplasmic vesicle
GO:0035556 TAS intracellular signal transduction
GO:0042169 IDA SH2 domain binding
GO:0042802 IPI identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043065 TAS positive regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0043122 IMP regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 IDA ubiquitin binding
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0046578 NAS regulation of Ras protein signal transduction
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051291 IEA protein heterooligomerization
GO:0070062 IDA extracellular vesicular exosome
GO:0070530 IEA K63-linked polyubiquitin binding
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075014 sqstm1 protein_coding Danio_rerio
ENSMUSG00000015837 Sqstm1 protein_coding Mus_musculus

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