ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163399 ATP1A1 9606 + 1:116372668-116410261 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295598 ATP1A1-001 116373260-116404774 protein_coding
  ENST00000369494 ATP1A1-002 116382411-116388663 protein_coding
  ENST00000369496 ATP1A1-201 116383370-116404772 protein_coding
  ENST00000418797 ATP1A1-008 116372668-116388155 protein_coding
  ENST00000440951 ATP1A1-006 116399471-116410261 protein_coding
  ENST00000463382 ATP1A1-004 116387303-116388525 processed_transcript
  ENST00000479960 ATP1A1-005 116401130-116402033 processed_transcript
  ENST00000488733 ATP1A1-009 116373269-116386144 retained_intron
  ENST00000491156 ATP1A1-003 116388727-116389940 processed_transcript
  ENST00000495965 ATP1A1-007 116406109-116410261 processed_transcript
  ENST00000537345 ATP1A1-202 116373867-116404772 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000295598ENST00000369496ENST00000440951
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000295598 25.825±4.45 184.144±69.79 20.988±0.00 144.640±0.00 70.101±38.11
ENST00000369496 73.596±1.98 64.805±8.67 35.420±0.00 N/A 39.590±20.90
ENST00000440951 159.489±17.99 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00012S CIL_00012S_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0002026 IEA regulation of the force of heart contraction
GO:0002028 ISS regulation of sodium ion transport
GO:0005391 ISS:IEA sodium:potassium-exchanging ATPase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005768 IEA endosome
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005890 IDA sodium:potassium-exchanging ATPase complex
GO:0005901 IEA caveola
GO:0006754 IEA ATP biosynthetic process
GO:0006813 IEA potassium ion transport
GO:0006814 IEA sodium ion transport
GO:0006883 IDA cellular sodium ion homeostasis
GO:0008217 IEA regulation of blood pressure
GO:0010107 IDA potassium ion import
GO:0016020 TAS membrane
GO:0016021 ISS:IEA integral component of membrane
GO:0016311 IEA dephosphorylation
GO:0016323 IEA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016791 IEA phosphatase activity
GO:0019901 IEA protein kinase binding
GO:0019904 IEA protein domain specific binding
GO:0030007 IDA cellular potassium ion homeostasis
GO:0030315 IEA T-tubule
GO:0030506 IEA ankyrin binding
GO:0030955 IEA potassium ion binding
GO:0031402 IEA sodium ion binding
GO:0031947 IEA negative regulation of glucocorticoid biosynthetic process
GO:0031982 IDA vesicle
GO:0034220 TAS ion transmembrane transport
GO:0036376 IDA sodium ion export from cell
GO:0042383 ISS sarcolemma
GO:0042493 IEA response to drug
GO:0043234 IDA protein complex
GO:0043531 IEA ADP binding
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0045121 IEA membrane raft
GO:0045822 IEA negative regulation of heart contraction
GO:0045823 IEA positive regulation of heart contraction
GO:0045989 IEA positive regulation of striated muscle contraction
GO:0046872 IEA metal ion binding
GO:0051087 IPI chaperone binding
GO:0055085 TAS transmembrane transport
GO:0055119 TAS relaxation of cardiac muscle
GO:0060048 TAS cardiac muscle contraction
GO:0060081 IEA membrane hyperpolarization
GO:0070062 IDA extracellular vesicular exosome
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071383 IDA cellular response to steroid hormone stimulus
GO:0086004 IEA regulation of cardiac muscle cell contraction
GO:0086009 IDA membrane repolarization
GO:0086013 IC membrane repolarization during cardiac muscle cell action potential
GO:0086064 TAS cell communication by electrical coupling involved in cardiac conduction
GO:1903416 IDA response to glycoside
GO:1990239 IDA steroid hormone binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001870 atp1a1a.4 protein_coding Danio_rerio
ENSDARG00000002791 atp1a1a.1 protein_coding Danio_rerio
ENSDARG00000007739 atp1a1a.2 protein_coding Danio_rerio
ENSDARG00000019856 atp1a1b protein_coding Danio_rerio
ENSDARG00000039131 atp1a1a.3 protein_coding Danio_rerio
ENSDARG00000040252 atp1a1a.5 protein_coding Danio_rerio
ENSMUSG00000033161 Atp1a1 protein_coding Mus_musculus

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