ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163738 MTHFD2L 9606 + 4:74114174-74303099 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000325278 MTHFD2L-001 74158173-74303099 protein_coding
  ENST00000359107 MTHFD2L-011 74158150-74281550 protein_coding
  ENST00000395759 MTHFD2L-201 74158112-74303092 protein_coding
  ENST00000423607 MTHFD2L-009 74158108-74183931 nonsense_mediated_decay
  ENST00000429335 MTHFD2L-008 74123344-74181750 nonsense_mediated_decay
  ENST00000429519 MTHFD2L-005 74114174-74242210 nonsense_mediated_decay
  ENST00000433372 MTHFD2L-202 74125438-74242197 protein_coding
  ENST00000461101 MTHFD2L-010 74158118-74162253 processed_transcript
  ENST00000461856 MTHFD2L-003 74224068-74301990 processed_transcript
  ENST00000465255 MTHFD2L-004 74280241-74302635 processed_transcript
  ENST00000475291 MTHFD2L-007 74123339-74160770 retained_intron
  ENST00000484725 MTHFD2L-012 74158175-74162106 processed_transcript
  ENST00000490128 MTHFD2L-013 74281425-74293675 processed_transcript
  ENST00000490698 MTHFD2L-006 74123273-74160514 retained_intron
  ENST00000492183 MTHFD2L-002 74194040-74302598 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000325278ENST00000359107ENST00000395759ENST00000423607ENST00000433372ENST00000461101ENST00000475291ENST00000484725ENST00000490698ENST00000492183
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000325278 N/A 0.535±0.20 N/A N/A 0.968±0.33
ENST00000359107 N/A N/A N/A N/A 1.815±0.25
ENST00000395759 N/A N/A N/A N/A 0.419±0.10
ENST00000423607 0.999±0.00 N/A N/A N/A N/A
ENST00000433372 N/A 0.794±0.18 N/A N/A N/A
ENST00000461101 1.441±0.18 1.761±1.50 3.545±0.00 2.557±0.00 2.047±0.80
ENST00000475291 N/A 2.246±1.19 N/A N/A 2.220±0.56
ENST00000484725 5.693±0.00 N/A N/A N/A N/A
ENST00000490698 9.238±2.22 2.045±0.58 N/A 3.328±0.00 5.699±2.43
ENST00000492183 N/A N/A N/A N/A 0.457±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00035M CIL_00035M_0001 CGP
CIL_0006SN CIL_0006SN_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000105 IEA histidine biosynthetic process
GO:0003824 IEA catalytic activity
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IBA methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IEA:IBA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005739 IBA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0006164 IEA purine nucleotide biosynthetic process
GO:0006730 IBA one-carbon metabolic process
GO:0009086 IEA methionine biosynthetic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0035999 IEA tetrahydrofolate interconversion
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054199 mthfd2l protein_coding Danio_rerio
ENSMUSG00000029376 Mthfd2l protein_coding Mus_musculus

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