ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: high mobility group box 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164104 HMGB2 9606 - 4:173331695-173335125 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296503 HMGB2-001 173331695-173335125 protein_coding
  ENST00000438704 HMGB2-004 173331701-173333672 protein_coding
  ENST00000446922 HMGB2-003 173331701-173334391 protein_coding
  ENST00000506267 HMGB2-005 173332889-173334249 protein_coding
  ENST00000511316 HMGB2-002 173331705-173334432 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000296503ENST00000438704ENST00000446922ENST00000506267ENST00000511316
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000296503 N/A 7.405±3.82 N/A N/A 18.731±15.91
ENST00000438704 22.849±10.91 24.600±17.22 42.932±0.00 55.944±0.00 30.722±20.37
ENST00000446922 23.752±5.09 16.890±9.36 5.500±0.00 22.944±0.00 31.567±30.84
ENST00000506267 N/A N/A N/A N/A 44.290±0.00
ENST00000511316 N/A 2.391±0.00 3.069±0.00 N/A 5.032±3.68

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00007T CIL_00007T_0002 CGP
CIL_0008VG CIL_0008VG_0001 VISTA
CIL_0008BZ CIL_0008BZ_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000793 IDA condensed chromosome
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0003677 IEA:IMP DNA binding
GO:0003684 IDA damaged DNA binding
GO:0003690 ISS double-stranded DNA binding
GO:0003697 ISS single-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006265 ISS DNA topological change
GO:0006288 IDA base-excision repair, DNA ligation
GO:0006309 TAS apoptotic DNA fragmentation
GO:0006325 NAS chromatin organization
GO:0006334 NAS nucleosome assembly
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007283 IEA spermatogenesis
GO:0007289 IEA spermatid nucleus differentiation
GO:0008301 IDA DNA binding, bending
GO:0008584 IEA male gonad development
GO:0019904 IEA protein domain specific binding
GO:0032075 IDA positive regulation of nuclease activity
GO:0033151 ISS V(D)J recombination
GO:0042056 IDA chemoattractant activity
GO:0043234 IDA protein complex
GO:0043388 IDA positive regulation of DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044822 IDA poly(A) RNA binding
GO:0045648 IMP positive regulation of erythrocyte differentiation
GO:0045654 IMP positive regulation of megakaryocyte differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048545 IEA response to steroid hormone
GO:0050786 IGI RAGE receptor binding
GO:0050918 IDA positive chemotaxis
GO:0051103 ISS DNA ligation involved in DNA repair
GO:0060326 IDA cell chemotaxis
GO:0071222 IEP cellular response to lipopolysaccharide
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029722 hmgb2a protein_coding Danio_rerio
ENSMUSG00000054717 Hmgb2 protein_coding Mus_musculus

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