ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166313 APBB1 9606 - 11:6395124-6419414 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299402 APBB1-002 6395125-6419070 protein_coding
  ENST00000311051 APBB1-001 6395125-6419414 protein_coding
  ENST00000389906 APBB1-201 6395124-6419111 protein_coding
  ENST00000524626 APBB1-010 6395158-6402784 retained_intron
  ENST00000526240 APBB1-020 6395125-6396574 processed_transcript
  ENST00000526925 APBB1-017 6401177-6404863 retained_intron
  ENST00000529519 APBB1-006 6395163-6405441 protein_coding
  ENST00000529778 APBB1-009 6401074-6402209 retained_intron
  ENST00000529890 APBB1-004 6401365-6404796 protein_coding
  ENST00000530885 APBB1-007 6395468-6404898 protein_coding
  ENST00000532020 APBB1-026 6403319-6419089 protein_coding
  ENST00000533139 APBB1-003 6401347-6404796 retained_intron
  ENST00000533407 APBB1-016 6401052-6419071 retained_intron
  ENST00000534188 APBB1-008 6401587-6404785 retained_intron
  ENST00000608394 APBB1-005 6395143-6405417 protein_coding
  ENST00000608435 APBB1-011 6395125-6419071 non_stop_decay
  ENST00000608645 APBB1-025 6395304-6405415 protein_coding
  ENST00000608655 APBB1-024 6395125-6404843 protein_coding
  ENST00000608704 APBB1-014 6395125-6405660 protein_coding
  ENST00000609331 APBB1-018 6395430-6404664 protein_coding
  ENST00000609360 APBB1-023 6395125-6419070 protein_coding
  ENST00000610474 APBB1-202 6395124-6405417 protein_coding
  ENST00000618005 APBB1-203 6395124-6405417 protein_coding
  ENST00000621678 APBB1-204 6395124-6404691 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000299402ENST00000311051ENST00000389906ENST00000524626ENST00000526240ENST00000529778ENST00000530885ENST00000533407ENST00000608435
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000299402 8.905±0.00 10.588±3.38 N/A 5.393±0.00 12.285±12.60
ENST00000311051 N/A 2.915±1.52 N/A N/A 3.637±0.70
ENST00000389906 N/A 3.386±1.37 N/A 2.742±0.00 6.755±5.40
ENST00000524626 39.203±2.22 7.588±1.38 N/A N/A 9.646±5.80
ENST00000526240 30.014±0.00 N/A 12.369±0.00 N/A N/A
ENST00000529778 N/A N/A N/A N/A 0.012±0.00
ENST00000530885 N/A 2.432±0.49 N/A N/A 7.067±3.81
ENST00000533407 N/A N/A N/A N/A 4.607±0.00
ENST00000608435 N/A 3.435±0.38 N/A 2.427±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0004AE CIL_0004AE_0001 CGP
CIL_0004N8 CIL_0004N8_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0001764 IEA neuron migration
GO:0003682 IDA chromatin binding
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006302 IEA double-strand break repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007050 ISS cell cycle arrest
GO:0007165 NAS signal transduction
GO:0007409 NAS axonogenesis
GO:0007411 IEA axon guidance
GO:0008134 ISS transcription factor binding
GO:0008542 IEA visual learning
GO:0030027 IDA lamellipodium
GO:0030198 IEA extracellular matrix organization
GO:0030308 ISS negative regulation of cell growth
GO:0030426 IDA growth cone
GO:0042393 IPI histone binding
GO:0043065 IDA positive regulation of apoptotic process
GO:0043967 ISS histone H4 acetylation
GO:0045202 IDA synapse
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045739 IEA positive regulation of DNA repair
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050760 ISS negative regulation of thymidylate synthase biosynthetic process
GO:0070064 IPI proline-rich region binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076560 apbb1 protein_coding Danio_rerio
ENSMUSG00000037032 Apbb1 protein_coding Mus_musculus

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