ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: mitogen-activated protein kinase kinase kinase kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168067 MAP4K2 9606 - 11:64788818-64803241 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000294066 MAP4K2-001 64789137-64803241 protein_coding
  ENST00000377350 MAP4K2-002 64789137-64803241 protein_coding
  ENST00000424945 MAP4K2-005 64789137-64796498 nonsense_mediated_decay
  ENST00000433890 MAP4K2-014 64789537-64803149 nonsense_mediated_decay
  ENST00000435926 MAP4K2-012 64788818-64803162 nonsense_mediated_decay
  ENST00000439069 MAP4K2-006 64799421-64803175 protein_coding
  ENST00000444560 MAP4K2-013 64801710-64803227 nonsense_mediated_decay
  ENST00000467689 MAP4K2-009 64796971-64799634 retained_intron
  ENST00000468062 MAP4K2-010 64800348-64803129 processed_transcript
  ENST00000470088 MAP4K2-004 64789137-64797343 retained_intron
  ENST00000482314 MAP4K2-007 64800336-64803010 processed_transcript
  ENST00000489952 MAP4K2-008 64789889-64799659 retained_intron
  ENST00000493428 MAP4K2-011 64800182-64801813 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000294066ENST00000377350ENST00000424945ENST00000433890ENST00000435926ENST00000470088ENST00000489952
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000294066 4.776±0.00 6.044±2.36 7.898±0.00 5.024±0.00 11.704±10.18
ENST00000377350 N/A 4.895±3.06 N/A N/A 4.432±2.90
ENST00000424945 29.036±4.63 8.890±1.68 31.764±0.00 N/A 6.257±0.21
ENST00000433890 N/A 6.222±1.63 N/A N/A 3.354±2.27
ENST00000435926 3.930±0.00 1.729±0.44 N/A 1.400±0.00 3.425±2.10
ENST00000470088 4.011±0.51 N/A 7.767±0.00 2.875±0.00 N/A
ENST00000489952 N/A 6.333±0.00 N/A N/A 2.395±2.24

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0005JE CIL_0005JE_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0006903 IEA vesicle targeting
GO:0006955 TAS immune response
GO:0007254 TAS JNK cascade
GO:0007257 IDA activation of JUN kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0035556 IDA intracellular signal transduction
GO:0045087 IEA innate immune response
GO:0046330 IDA positive regulation of JNK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001234 map4k2 protein_coding Danio_rerio
ENSDARG00000033444 map4k6 protein_coding Danio_rerio
ENSMUSG00000024948 Map4k2 protein_coding Mus_musculus

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