ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169598 DFFB 9606 + 1:3857267-3885429 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338895 DFFB-201 3857267-3885420 protein_coding
  ENST00000339350 DFFB-004 3857473-3885429 nonsense_mediated_decay
  ENST00000341385 DFFB-202 3857604-3883741 protein_coding
  ENST00000378206 DFFB-007 3857517-3885429 nonsense_mediated_decay
  ENST00000378209 DFFB-001 3857281-3885429 protein_coding
  ENST00000461150 DFFB-009 3883507-3885429 nonsense_mediated_decay
  ENST00000468793 DFFB-002 3857460-3885429 nonsense_mediated_decay
  ENST00000475969 DFFB-006 3857600-3885429 nonsense_mediated_decay
  ENST00000477548 DFFB-003 3857473-3885429 nonsense_mediated_decay
  ENST00000481945 DFFB-008 3867663-3872545 retained_intron
  ENST00000491998 DFFB-005 3857281-3885429 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000338895ENST00000339350ENST00000341385ENST00000378206ENST00000378209ENST00000461150ENST00000468793ENST00000475969ENST00000477548ENST00000491998
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000338895 N/A 0.522±0.12 N/A N/A 0.869±0.61
ENST00000339350 N/A N/A N/A N/A 0.026±0.00
ENST00000341385 N/A 1.451±0.05 N/A N/A 0.097±0.00
ENST00000378206 N/A N/A 0.494±0.00 N/A N/A
ENST00000378209 N/A 0.950±0.41 N/A 3.132±0.00 1.717±1.13
ENST00000461150 2.468±0.15 2.192±0.70 3.308±0.00 N/A 2.661±0.20
ENST00000468793 0.455±0.00 0.807±0.11 N/A N/A 0.391±0.23
ENST00000475969 0.896±0.24 N/A N/A N/A N/A
ENST00000477548 N/A 0.398±0.00 N/A N/A N/A
ENST00000491998 N/A 0.665±0.38 N/A N/A 0.507±0.02

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0003677 IEA DNA binding
GO:0004518 IEA nuclease activity
GO:0004536 IEA deoxyribonuclease activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006309 IEA apoptotic DNA fragmentation
GO:0006915 IEA apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007420 IEA brain development
GO:0016787 IEA hydrolase activity
GO:0019899 IPI enzyme binding
GO:0030263 IDA apoptotic chromosome condensation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009748 dffb protein_coding Danio_rerio
ENSMUSG00000029027 Dffb protein_coding Mus_musculus

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