ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SRY (sex determining region Y)-box 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000181449 SOX2 9606 + 3:181711924-181714436 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000325404 SOX2-001 181711924-181714436 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHMVEC-DHUVECENST00000325404
Transcript ID HAoEC HHSEC HMVEC-D HUVEC
ENST00000325404 0.068±0.06 0.069±0.00 0.375±0.00 0.061±0.05

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007MF CIL_0007MF_0001 UCNEbase
CIL_0005FX CIL_0005FX_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IEA transcription regulatory region sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001649 IDA osteoblast differentiation
GO:0001654 IEP eye development
GO:0001708 IEA cell fate specification
GO:0001714 IDA endodermal cell fate specification
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0003677 IDA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 TAS transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006325 NAS chromatin organization
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007050 IDA cell cycle arrest
GO:0007605 IEA sensory perception of sound
GO:0009611 IEP response to wounding
GO:0010033 IEA response to organic substance
GO:0010468 IMP regulation of gene expression
GO:0019827 IEA stem cell maintenance
GO:0021781 NAS glial cell fate commitment
GO:0021879 IEA forebrain neuron differentiation
GO:0021983 IEP pituitary gland development
GO:0021984 IEA adenohypophysis development
GO:0021987 IEA cerebral cortex development
GO:0022409 IEA positive regulation of cell-cell adhesion
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030539 IEA male genitalia development
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0030900 IEP forebrain development
GO:0030910 IEA olfactory placode formation
GO:0032526 IEA response to retinoic acid
GO:0035019 IMP somatic stem cell maintenance
GO:0035198 IDA miRNA binding
GO:0042246 IEA tissue regeneration
GO:0042472 IEA inner ear morphogenesis
GO:0043281 IDA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043565 IDA sequence-specific DNA binding
GO:0043586 IEA tongue development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044798 IEA nuclear transcription factor complex
GO:0045165 IEA cell fate commitment
GO:0045596 IEA negative regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045747 IEA positive regulation of Notch signaling pathway
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046148 IEA pigment biosynthetic process
GO:0046982 IEA protein heterodimerization activity
GO:0048286 IEA lung alveolus development
GO:0048568 IEA embryonic organ development
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048663 IEA neuron fate commitment
GO:0048839 IEP inner ear development
GO:0048852 IEA diencephalon morphogenesis
GO:0048863 IEA stem cell differentiation
GO:0050680 IDA negative regulation of epithelial cell proliferation
GO:0050767 IEA regulation of neurogenesis
GO:0050910 IEA detection of mechanical stimulus involved in sensory perception of sound
GO:0050973 IEA detection of mechanical stimulus involved in equilibrioception
GO:0060042 IEA retina morphogenesis in camera-type eye
GO:0060235 IEA lens induction in camera-type eye
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0070848 IDA response to growth factor
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:0097150 ISS neuronal stem cell maintenance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070913 sox2 protein_coding Danio_rerio
ENSMUSG00000074637 Sox2 protein_coding Mus_musculus

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