ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: LCK proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182866 LCK 9606 + 1:32251239-32286165 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333070 LCK-004 32274132-32286162 protein_coding
  ENST00000336890 LCK-001 32251239-32286165 protein_coding
  ENST00000355928 LCK-014 32251275-32275255 retained_intron
  ENST00000373557 LCK-010 32274121-32276428 protein_coding
  ENST00000373562 LCK-013 32274115-32275604 protein_coding
  ENST00000373564 LCK-201 32251239-32286164 protein_coding
  ENST00000461712 LCK-012 32274113-32275078 protein_coding
  ENST00000469765 LCK-007 32251318-32286160 retained_intron
  ENST00000469956 LCK-003 32275620-32277173 retained_intron
  ENST00000476457 LCK-009 32251298-32275446 retained_intron
  ENST00000477031 LCK-011 32274121-32275002 protein_coding
  ENST00000482949 LCK-002 32251264-32275618 protein_coding
  ENST00000495610 LCK-006 32251274-32279909 protein_coding
  ENST00000619559 LCK-202 32274111-32286164 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000333070ENST00000373557ENST00000373564ENST00000469765ENST00000469956ENST00000495610ENST00000619559
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000333070 N/A N/A 0.984±0.00 N/A N/A
ENST00000373557 N/A N/A N/A N/A 0.037±0.00
ENST00000373564 N/A 0.017±0.00 N/A N/A 0.031±0.00
ENST00000469765 N/A N/A 0.792±0.00 N/A 0.029±0.02
ENST00000469956 0.185±0.00 0.116±0.07 N/A 0.183±0.00 0.115±0.09
ENST00000495610 N/A N/A N/A N/A 0.107±0.00
ENST00000619559 N/A 0.071±0.06 0.671±0.00 N/A 0.043±0.03

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008AA CIL_0008AA_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000242 ISS pericentriolar material
GO:0001772 IDA immunological synapse
GO:0001948 IPI glycoprotein binding
GO:0003823 IEA antigen binding
GO:0004672 IEA protein kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0004722 ISS protein serine/threonine phosphatase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0006882 ISS cellular zinc ion homeostasis
GO:0006915 IEA apoptotic process
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008022 IPI protein C-terminus binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009612 IEA response to mechanical stimulus
GO:0010038 IEA response to metal ion
GO:0010043 IEA response to zinc ion
GO:0010628 IEA positive regulation of gene expression
GO:0016032 TAS viral process
GO:0016311 ISS dephosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0030097 NAS hemopoiesis
GO:0030139 IEA endocytic vesicle
GO:0030168 TAS platelet activation
GO:0030217 ISS T cell differentiation
GO:0031295 TAS T cell costimulation
GO:0032403 IEA protein complex binding
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042169 ISS SH2 domain binding
GO:0042493 ISS response to drug
GO:0042523 IEA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542 IEA response to hydrogen peroxide
GO:0042609 IPI CD4 receptor binding
GO:0042610 IPI CD8 receptor binding
GO:0042802 IPI identical protein binding
GO:0043548 IPI phosphatidylinositol 3-kinase binding
GO:0045087 TAS innate immune response
GO:0045121 ISS membrane raft
GO:0045588 IEA positive regulation of gamma-delta T cell differentiation
GO:0046777 IEA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050852 TAS T cell receptor signaling pathway
GO:0050853 IEA B cell receptor signaling pathway
GO:0050856 IEA regulation of T cell receptor signaling pathway
GO:0050862 NAS positive regulation of T cell receptor signaling pathway
GO:0050870 ISS positive regulation of T cell activation
GO:0050900 TAS leukocyte migration
GO:0051117 IPI ATPase binding
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051249 NAS regulation of lymphocyte activation
GO:0070062 IDA extracellular vesicular exosome
GO:0070474 IEA positive regulation of uterine smooth muscle contraction
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000000409 Lck protein_coding Mus_musculus

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