ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: checkpoint kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000183765 CHEK2 9606 - 22:28687743-28742422 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000328354 CHEK2-002 28687744-28741844 protein_coding
  ENST00000348295 CHEK2-201 28687743-28741834 protein_coding
  ENST00000382565 CHEK2-202 28721600-28741834 protein_coding
  ENST00000382580 CHEK2-003 28687763-28741838 protein_coding
  ENST00000398017 CHEK2-012 28725083-28741802 protein_coding
  ENST00000402731 CHEK2-022 28687897-28734721 protein_coding
  ENST00000403642 CHEK2-021 28687897-28734721 protein_coding
  ENST00000404276 CHEK2-006 28687744-28734721 protein_coding
  ENST00000405598 CHEK2-005 28687762-28741800 protein_coding
  ENST00000416671 CHEK2-001 28687743-28742422 nonsense_mediated_decay
  ENST00000417588 CHEK2-009 28687887-28734721 nonsense_mediated_decay
  ENST00000425190 CHEK2-011 28696968-28741811 protein_coding
  ENST00000433028 CHEK2-004 28696902-28741806 nonsense_mediated_decay
  ENST00000433728 CHEK2-023 28687887-28734721 nonsense_mediated_decay
  ENST00000434810 CHEK2-018 28687743-28711931 protein_coding
  ENST00000439200 CHEK2-013 28711909-28741783 protein_coding
  ENST00000439346 CHEK2-015 28699764-28725248 nonsense_mediated_decay
  ENST00000447421 CHEK2-010 28696901-28734727 protein_coding
  ENST00000448511 CHEK2-008 28687887-28734721 nonsense_mediated_decay
  ENST00000454252 CHEK2-014 28724965-28730501 nonsense_mediated_decay
  ENST00000456369 CHEK2-019 28687743-28711955 protein_coding
  ENST00000464581 CHEK2-017 28696923-28712146 protein_coding
  ENST00000472807 CHEK2-020 28687749-28689410 retained_intron
  ENST00000491919 CHEK2-016 28696944-28712257 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000328354ENST00000348295ENST00000382565ENST00000382580ENST00000417588ENST00000425190ENST00000433728ENST00000434810ENST00000448511
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000328354 N/A 2.565±0.12 N/A N/A 3.226±0.94
ENST00000348295 2.953±0.00 N/A N/A N/A 2.643±0.86
ENST00000382565 N/A 7.238±1.18 N/A N/A 7.245±3.07
ENST00000382580 N/A N/A N/A 1.708±0.00 1.316±0.39
ENST00000417588 N/A N/A N/A N/A 1.945±0.00
ENST00000425190 N/A 3.552±0.11 N/A N/A N/A
ENST00000433728 N/A 2.547±0.57 N/A N/A 2.176±0.25
ENST00000434810 6.941±0.48 4.009±0.58 3.751±0.00 4.947±0.00 3.120±0.00
ENST00000448511 N/A N/A N/A N/A 0.935±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008NO CIL_0008NO_0001 VISTA
CIL_0006WX CIL_0006WX_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 TAS DNA damage checkpoint
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000781 IDA chromosome, telomeric region
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0006302 IMP double-strand break repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006975 IMP DNA damage induced protein phosphorylation
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 IEA response to gamma radiation
GO:0016301 IEA kinase activity
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IPI protein kinase binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0042176 IMP regulation of protein catabolic process
GO:0042770 IDA signal transduction in response to DNA damage
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0044257 IMP cellular protein catabolic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046777 IDA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0050821 IDA protein stabilization
GO:0072428 IMP signal transduction involved in intra-S DNA damage checkpoint
GO:0090307 IMP spindle assembly involved in mitosis
GO:0090399 NAS replicative senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025820 chek2 protein_coding Danio_rerio
ENSMUSG00000029521 Chek2 protein_coding Mus_musculus

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