ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: major histocompatibility complex, class II, DR beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196126 HLA-DRB1 9606 - 6:32552990-32589848 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360004 HLA-DRB1-001 32578769-32589848 protein_coding
  ENST00000611060 HLA-DRB1-201 32552990-32589805 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000360004ENST00000611060
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000360004 0.680±0.00 0.299±0.23 151.544±0.00 N/A 0.348±0.44
ENST00000611060 N/A 0.183±0.02 N/A 0.169±0.00 0.089±0.07

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0001PK CIL_0001PK_0002 CGP
CIL_0002XS CIL_0002XS_0008 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002381 ISS immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002437 ISS inflammatory response to antigenic stimulus
GO:0002455 ISS humoral immune response mediated by circulating immunoglobulin
GO:0002506 IDA polysaccharide assembly with MHC class II protein complex
GO:0005515 IEA protein binding
GO:0005765 IDA lysosomal membrane
GO:0005886 TAS plasma membrane
GO:0006955 ISS:IEA immune response
GO:0009897 ISS external side of plasma membrane
GO:0009986 IDA cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA:NAS:IEA membrane
GO:0016045 ISS detection of bacterium
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 IDA MHC class II protein complex binding
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0031902 IDA late endosome membrane
GO:0032395 NAS MHC class II receptor activity
GO:0032588 TAS trans-Golgi network membrane
GO:0032673 ISS regulation of interleukin-4 production
GO:0032689 ISS negative regulation of interferon-gamma production
GO:0035774 ISS positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042088 ISS T-helper 1 type immune response
GO:0042130 ISS negative regulation of T cell proliferation
GO:0042605 IDA:ISS peptide antigen binding
GO:0042613 IDA:IEA:ISS MHC class II protein complex
GO:0050852 TAS T cell receptor signaling pathway
GO:0051262 ISS protein tetramerization
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:2001179 ISS regulation of interleukin-10 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041705 si:busm1-228j01.6 protein_coding Danio_rerio
ENSDARG00000056330 mhc2dbb protein_coding Danio_rerio
ENSDARG00000074510 si:busm1-104n07.3 protein_coding Danio_rerio
ENSDARG00000076307 si:zfos-2070c2.3 protein_coding Danio_rerio
ENSDARG00000079105 mhc2dab protein_coding Danio_rerio
ENSDARG00000088872 si:busm1-228j01.4 protein_coding Danio_rerio
ENSMUSG00000060586 H2-Eb1 protein_coding Mus_musculus
ENSMUSG00000067341 H2-Eb2 protein_coding Mus_musculus

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