ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: siah E3 ubiquitin protein ligase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196470 SIAH1 9606 - 16:48356364-48448402 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356721 SIAH1-001 48360531-48365901 protein_coding
  ENST00000380006 SIAH1-003 48360531-48363882 protein_coding
  ENST00000394725 SIAH1-002 48360531-48385450 protein_coding
  ENST00000563745 SIAH1-006 48362133-48393955 protein_coding
  ENST00000565620 SIAH1-007 48356364-48361792 processed_transcript
  ENST00000567973 SIAH1-005 48387198-48417319 processed_transcript
  ENST00000568007 SIAH1-004 48356364-48448402 nonsense_mediated_decay
  ENST00000573005 SIAH1-008 48364850-48365724 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000380006ENST00000394725
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000380006 N/A N/A 7.112±0.00 N/A 4.218±1.31
ENST00000394725 3.700±0.54 5.247±0.70 26.908±0.00 9.839±0.00 7.902±3.25

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002VR CIL_0002VR_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS:IEA nucleus
GO:0005737 TAS cytoplasm
GO:0005769 IEA early endosome
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006508 TAS proteolysis
GO:0006511 IEA:IDA ubiquitin-dependent protein catabolic process
GO:0006915 TAS apoptotic process
GO:0007049 IEA cell cycle
GO:0007275 IEA multicellular organismal development
GO:0007283 IEA spermatogenesis
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0008022 IPI protein C-terminus binding
GO:0008270 IEA:ISS zinc ion binding
GO:0009653 TAS anatomical structure morphogenesis
GO:0016874 IEA ligase activity
GO:0030163 IDA protein catabolic process
GO:0030877 IDA beta-catenin destruction complex
GO:0031648 IEA protein destabilization
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051402 ISS neuron apoptotic process
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030871 siah1 protein_coding Danio_rerio
ENSMUSG00000036840 Siah1a protein_coding Mus_musculus
ENSMUSG00000040749 Siah1b protein_coding Mus_musculus

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