ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: complement component 5a receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197405 C5AR1 9606 + 19:47290023-47322066 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355085 C5AR1-003 47309874-47322066 protein_coding
  ENST00000594787 C5AR1-002 47297075-47320186 protein_coding
  ENST00000595501 C5AR1-001 47290023-47307754 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000355085ENST00000594787ENST00000595501
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000355085 0.078±0.01 0.162±0.11 4.898±0.00 0.203±0.00 0.131±0.21
ENST00000594787 N/A 0.164±0.09 N/A N/A 0.107±0.06
ENST00000595501 1.163±0.00 0.448±0.30 N/A 0.679±0.00 0.352±0.20

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008G1 CIL_0008G1_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0001856 IEA complement component C5a binding
GO:0002430 IEA complement receptor mediated signaling pathway
GO:0004878 IDA complement component C5a receptor activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0004944 IDA C5a anaphylatoxin receptor activity
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006915 IEA apoptotic process
GO:0006935 TAS chemotaxis
GO:0006954 IEA inflammatory response
GO:0006955 TAS immune response
GO:0006968 TAS cellular defense response
GO:0007165 TAS signal transduction
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007606 TAS sensory perception of chemical stimulus
GO:0009986 IEA cell surface
GO:0016021 IEA integral component of membrane
GO:0016323 IDA basolateral plasma membrane
GO:0021534 IEA cell proliferation in hindbrain
GO:0030593 IEA neutrophil chemotaxis
GO:0031100 IEA organ regeneration
GO:0032494 IEA response to peptidoglycan
GO:0032496 IEA response to lipopolysaccharide
GO:0038178 IDA complement component C5a signaling pathway
GO:0042789 IDA mRNA transcription from RNA polymerase II promoter
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045177 IDA apical part of cell
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0050830 IEA defense response to Gram-positive bacterium
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040319 c5ar1 protein_coding Danio_rerio
ENSMUSG00000049130 C5ar1 protein_coding Mus_musculus

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