ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: purine nucleoside phosphorylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198805 PNP 9606 + 14:20468954-20477094 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361505 PNP-001 20469379-20477094 protein_coding
  ENST00000553418 PNP-007 20468954-20474571 protein_coding
  ENST00000553591 PNP-010 20469541-20475146 protein_coding
  ENST00000554056 PNP-005 20469414-20477058 retained_intron
  ENST00000554065 PNP-009 20470526-20474908 protein_coding
  ENST00000556293 PNP-002 20469406-20473200 retained_intron
  ENST00000556754 PNP-006 20473384-20477087 retained_intron
  ENST00000557229 PNP-003 20469406-20475163 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000361505ENST00000553418ENST00000554056ENST00000556754
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000361505 96.087±7.99 198.998±62.10 23.530±0.00 145.036±0.00 103.114±64.83
ENST00000553418 N/A 51.410±0.00 N/A N/A 394.647±341.17
ENST00000554056 N/A N/A 13.235±0.00 N/A 11.130±7.15
ENST00000556754 N/A N/A N/A N/A 2.742±2.82

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0001O9 CIL_0001O9_0001 CGP
CIL_0002RW CIL_0002RW_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001882 IDA nucleoside binding
GO:0002060 IDA purine nucleobase binding
GO:0003824 IEA catalytic activity
GO:0004731 IDA:IEA purine-nucleoside phosphorylase activity
GO:0005622 IDA intracellular
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006139 IDA:IEA nucleobase-containing compound metabolic process
GO:0006144 TAS purine nucleobase metabolic process
GO:0006148 IDA inosine catabolic process
GO:0006195 TAS purine nucleotide catabolic process
GO:0006738 IDA nicotinamide riboside catabolic process
GO:0006955 IMP immune response
GO:0008144 IDA drug binding
GO:0009116 IEA nucleoside metabolic process
GO:0034356 IGI NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0034418 IDA urate biosynthetic process
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042301 IDA phosphate ion binding
GO:0042493 IMP response to drug
GO:0043101 TAS purine-containing compound salvage
GO:0044281 TAS small molecule metabolic process
GO:0046638 IDA positive regulation of alpha-beta T cell differentiation
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0070970 IMP interleukin-2 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078619 pnp5a protein_coding Danio_rerio
ENSMUSG00000021871 Pnp protein_coding Mus_musculus
ENSMUSG00000068417 Pnp2 protein_coding Mus_musculus

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