ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: inducible T-cell co-stimulator ligand
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000277117 ICOSLG 9606 + 21:5022493-5040666 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000612610 ICOSLG-003 5022493-5040661 protein_coding
  ENST00000620481 ICOSLG-201 5022493-5040666 protein_coding
  ENST00000623795 ICOSLG-004 5022533-5036125 protein_coding
  ENST00000623903 ICOSLG-002 5022531-5034684 nonsense_mediated_decay
  ENST00000623960 ICOSLG-001 5022494-5036771 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000620481ENST00000623795ENST00000623903ENST00000623960
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000620481 N/A 0.063±0.02 N/A 0.215±0.00 0.049±0.03
ENST00000623795 N/A N/A N/A N/A 0.022±0.01
ENST00000623903 N/A N/A N/A N/A 0.010±0.00
ENST00000623960 0.260±0.00 0.021±0.00 0.017±0.00 0.193±0.00 0.173±0.15

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00066U CIL_00066U_0001 CGP
CIL_00066M CIL_00066M_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005102 TAS receptor binding
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0006952 NAS defense response
GO:0006972 NAS hyperosmotic response
GO:0007165 NAS signal transduction
GO:0016021 NAS integral component of membrane
GO:0031295 TAS T cell costimulation
GO:0042104 TAS positive regulation of activated T cell proliferation
GO:0042110 NAS T cell activation
GO:0042113 IEA B cell activation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000000732 Icosl protein_coding Mus_musculus

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